Results 251 to 260 of about 119,693 (290)

Adenosine A1 receptors and erythropoietin production

American Journal of Physiology-Cell Physiology, 1993
N6-cyclopentyladenosine (CPA), a selective adenosine A1 receptor agonist, in a concentration range of 10(-9) to 10(-7) M, produced a significant decrease in erythropoietin (EPO) levels in a human hepatocellular carcinoma (Hep G2) cell culture (medium levels of EPO, 91.81 +/- 1.61 and 94.36 +/- 0.97% of control, respectively) after 24 h incubation in a
James W. Fisher, J. Brookins, Takashi Ohigashi   +2 more
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Adenosine A1 receptor antagonists and the kidney

Current Opinion in Nephrology and Hypertension, 2003
This review will examine the most recent evidence that adenosine receptors in the kidney can alter kidney function. Adenosine A(1)-receptors located in the afferent arteriole and proximal tubule can contribute to fluid retaining disorders by mediating tubuloglomerular feedback, afferent arteriole vasoconstriction or direct sodium absorption.
William J. Welch, Paul S Modlinger
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Binding thermodynamics at A1 and A2a adenosine receptors

Life Sciences, 1996
Only recently the binding equilibrium of a number of ligands at adenosine A1 and A2a receptors has been analyzed from a thermodynamic point of view. This approach presents the advantage, with respect to usual affinity constant measurements, of a greater capability to give information about the molecular mechanisms underlying the binding process.
BOREA, Pier Andrea, DALPIAZ, Alessandro, VARANI, Katia, GESSI, Stefania, GILLI, Gastone   +4 more
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The role of adenosine A1 receptor on immune cells

Inflammation Research, 2022
Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A1 receptor (A1R)-mediated adenosine signaling pathway in the ...
Lingyu, Zhong, Qiao, Peng, Xun, Zeng
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Allosteric modulation of A1-adenosine receptor: a review

Drug Discovery Today: Technologies, 2013
Allosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased.
M. Kimatrai Salvador, BARALDI, Pier Giovanni, ROMAGNOLI, Romeo   +2 more
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Adenosine receptor modelling. A1/A2a selectivity

European Journal of Medicinal Chemistry, 2006
Three-dimensional models of the A(1) and A(2a) adenosine receptors (AR) were constructed by means of a homology procedure, using bovine rhodopsin as a template. In order to validate the two models, a docking analysis of selective agonists was carried out.
TUCCINARDI, TIZIANO, ORTORE, GABRIELLA MARIA PIA, MANERA, CLEMENTINA, SACCOMANNI, GIUSEPPE, MARTINELLI, ADRIANO   +4 more
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4 The Adenosine A1 Receptor and its Ligands

2009
Publisher Summary This chapter discusses the adenosine A1 receptor and its ligands. The adenosine A1 receptor is a G-protein-coupled receptor of about 36 kDa with even transmembrane domain structure. Adenosine and adenosine A1 receptors are involved in the modulation of several physiological effects in heart, kidney, CNS, and lipid metabolism ...
Barbara Albrecht-Küpper, Peter Nell
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Allosteric Enhancers for A1 Adenosine Receptor

Mini-Reviews in Medicinal Chemistry, 2007
Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents.
BARALDI, Pier Giovanni, IACONINOTO, Antonietta, MOORMAN AR, CARRION MD, CARA CL, PRETI, Delia, LOPEZ OC, FRUTTAROLO, Francesca, AGHAZADEH TABRIZI, Mojgan, ROMAGNOLI, Romeo   +9 more
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Inverse agonism at adenosine A1 receptors

International Congress Series, 2003
Abstract Inverse agonism at adenosine A1 receptors was studied in a variety of experimental set-ups. As a read-out, the binding of [35S]GTPγS to membranes of either CHO or COS-7 cells expressing human adenosine A1 receptors was used. When wild-type receptors were studied, inverse agonism could only be detected at higher levels of receptor expression.
Anna Lorenzen, Rianne A.F de Ligt, Adriaan P. IJzerman   +2 more
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Alterations of adenosine A1 receptors in morphine dependence

Brain Research, 1994
The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors ...
Gary B. Kaplan, Kimberly A Leite-Morris, Mary T. Sears   +2 more
openaire   +3 more sources