Results 241 to 250 of about 59,314 (277)

Pentacycle derivatives as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB-1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of pentacycle derivatives.
Suk Ho, Lee, Hee Jeong, Seo, Min Ju, Kim, Suk Youn, Kang, Sung-Han, Lee, Kwangwoo, Ahn, Minwoo, Lee, Ho-Kyun, Han, Jeongmin, Kim, Jinhwa, Lee   +9 more
openaire   +2 more sources

Substituted pyrimidines as cannabinoid CB1 receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2009
Cannabinoid CB1 receptors have been the avenue of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series of substituted pyrimidines based ...
Min Ju, Kim, Jong Yup, Kim, Hee Jeong, Seo, Junwon, Lee, Sung-Han, Lee, Mi-Soon, Kim, Jahyo, Kang, Jeongmin, Kim, Jinhwa, Lee   +8 more
openaire   +2 more sources

CB1 cannabinoid receptor induction in experimental stroke

Annals of Neurology, 2000
Cannabinoids protect cortical neurons from ischemic injury by interacting with CB1 receptors. Because a variety of neuroprotective genes are induced in cerebral ischemia, we examined the effect of experimental stroke, produced by 20 minutes of middle cerebral artery occlusion in rats, on CB1 receptor expression.
K L, Jin, X O, Mao, P C, Goldsmith, D A, Greenberg   +3 more
openaire   +2 more sources

Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

Molecular Pharmacology, 1995
The recently cloned CB2 cannabinoid receptor subtype was stably transfected into AtT-20 and Chinese hamster ovary cells to compare the binding and signal transduction properties of this receptor with those of the CB1 receptor subtype.
C. Felder, K. E. Joyce, E. M. Briley, J. Mansouri, K. Mackie, O. Blond, Y. Lai, A. Ma, R. Mitchell   +8 more
semanticscholar   +1 more source

Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2008
Cannabinoid CB1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed a new series of tetrazole-biarylpyrazoles.
Suk Youn, Kang, Sung-Han, Lee, Hee Jeong, Seo, Myung Eun, Jung, Kwangwoo, Ahn, Jeongmin, Kim, Jinhwa, Lee   +6 more
openaire   +2 more sources

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Nature Chemical Biology, 2019
Zhenhua Shao, Wei-Qun Yan, Karen M. Chapman, Karthik Ramesh, A. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu, D. Rosenbaum   +8 more
semanticscholar   +1 more source

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.

Neuroscience, 2016
J. F. O. D. Cruz, Laurie M. Robin, F. Drago, G. Marsicano, G. Marsicano, M. Metna‐Laurent, M. Metna‐Laurent   +6 more
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system.

Neuroscience, 1998
K. Tsou, S. Brown, Sañudo-Peña Mc, K. Mackie, J. Walker   +4 more
semanticscholar   +1 more source

Cannabinoid CB1 receptors in epilepsy

2020
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openaire   +1 more source