Results 21 to 30 of about 11,404 (192)

Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential

Molecules, 2022
A series of novel cannabinoid-type derivatives were synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(−)-fenchones with various resorcinols/phenols.
Reem Smoum, Christeene Haj, Shira Hirsch, Alina Nemirovski, Zhannah Yekhtin, Benny Bogoslavsky, Gaganjyot Kaur Bakshi, Mukesh Chourasia, Ruth Gallily, Joseph Tam, Raphael Mechoulam   +10 more
doaj   +1 more source

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

Frontiers in Neuroscience, 2016
Over the past two decades, our understanding of the endocannabinoid system has greatly improved due to the wealth of results obtained from exploratory studies. Currently, two cannabinoid receptor subtypes have been well characterized.
Ahmed Haider, Adrienne Müller Herde, Roger Slavik, Markus Weber, Claudia Mugnaini, Alessia Ligresti, Roger Schibli, Linjing Mu, Simon Mensah Ametamey   +8 more
doaj   +1 more source

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration [PDF]

Acta Neuropathologica Communications, 2021
AbstractTauopathies are a group of neurodegenerative diseases characterized by the alteration/aggregation of TAU protein, for which there is still no effective treatment. Therefore, new pharmacological targets are being sought, such as elements of the endocannabinoid system (ECS).
M. Galán-Ganga, C. Rodríguez-Cueto, J. Merchán-Rubira, F. Hernández, J. Ávila, M. Posada-Ayala, J. L. Lanciego, E. Luengo, M. G. Lopez, A. Rábano, J. Fernández-Ruiz, I. Lastres-Becker   +11 more
openaire   +9 more sources

Functional CB2 type cannabinoid receptors at CNS synapses [PDF]

Neuropharmacology, 2009
To date, it has been thought that cannabinoid receptors in CNS are primarily of the CB1R subtype, with CB2R expressed only in glia and peripheral tissues. However, evidence for the expression of CB2 type cannabinoid receptors at neuronal sites in the CNS is building through anatomical localization of receptors and mRNA in neurons and behavioural ...
Nicola H, Morgan, Ian M, Stanford, Gavin L, Woodhall   +2 more
openaire   +2 more sources

New Perspectives in the Studies on Endocannabinoid and Cannabis: 2-Arachidonoylglycerol as a Possible Novel Mediator of Inflammation

Journal of Pharmacological Sciences, 2004
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors. To date, two types of cannabinoid receptors (CB1 and CB2) have been identified. The CB1 receptor is assumed to be involved in the attenuation of synaptic transmission.
Takayuki Sugiura, Saori Oka, Maiko Gokoh, Seishi Kishimoto, Keizo Waku   +4 more
doaj   +1 more source

Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor

Biomolecules, 2020
Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic factors acting through immunological and endocrine responses generate structural and functional ...
Graziela Vieira, Juliana Cavalli, Elaine C. D. Gonçalves, Saulo F. P. Braga, Rafaela S. Ferreira, Adair R. S. Santos, Maíra Cola, Nádia R. B. Raposo, Raffaele Capasso, Rafael C. Dutra   +9 more
doaj   +1 more source

Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats. [PDF]

PLoS ONE, 2014
The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper airway muscle activation/patency and disrupting respiratory rhythmogenesis.
Michael W Calik, David W Carley
doaj   +1 more source

Crystal Structure of the Human Cannabinoid Receptor CB2 [PDF]

Cell, 2019
The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic, and neurodegenerative diseases. Here, we report the crystal structure of human CB2 in complex with a rationally designed antagonist, AM10257, at 2.8 Å ...
Xiaoting, Li, Tian, Hua, Kiran, Vemuri, Jo-Hao, Ho, Yiran, Wu, Lijie, Wu, Petr, Popov, Othman, Benchama, Nikolai, Zvonok, K'ara, Locke, Lu, Qu, Gye Won, Han, Malliga R, Iyer, Resat, Cinar, Nathan J, Coffey, Jingjing, Wang, Meng, Wu, Vsevolod, Katritch, Suwen, Zhao, George, Kunos, Laura M, Bohn, Alexandros, Makriyannis, Raymond C, Stevens, Zhi-Jie, Liu   +23 more
openaire   +2 more sources

Microglial Cannabinoid CB2 Receptors in Pain Modulation

International Journal of Molecular Sciences, 2023
Pain, especially chronic pain, can strongly affect patients’ quality of life. Cannabinoids ponhave been reported to produce potent analgesic effects in different preclinical pain models, where they primarily function as agonists of Gi/o protein-coupled cannabinoid CB1 and CB2 receptors.
Kangtai Xu, Yifei Wu, Zhuangzhuang Tian, Yuanfan Xu, Chaoran Wu, Zilong Wang   +5 more
openaire   +2 more sources

CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity [PDF]

Journal of Psychopharmacology, 2011
There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are either activated by cannabinoids and/or endocannabinoids (eCBs). The neuronal and functional expression of CB2-Rs in the brain has been much less well characterized in comparison ...
Emmanuel S, Onaivi, Hiroki, Ishiguro, Shanzhi, Gu, Qing-Rong, Liu   +3 more
openaire   +2 more sources