Results 21 to 30 of about 1,265,475 (213)

Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells [PDF]

PeerJ, 2019
Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over
Shivani Sachdev, Rochelle Boyd, Natasha L. Grimsey, Marina Santiago, Mark Connor   +4 more
doaj   +2 more sources

Role of CB2 receptors in neuroprotective effects of cannabinoids [PDF]

Molecular and Cellular Endocrinology, 2008
CB2 receptors, the so-called peripheral cannabinoid receptor type, were first described in the immune system, but they have been recently identified in the brain in healthy conditions and, in particular, after several types of cytotoxic stimuli. Specifically, CB2 receptors were identified in microglial cells, astrocytes and, to a lesser extent, in ...
Fernández-Ruiz, Javier, Pazos, María Ruth, García-Arencibia, Moisés, Sagredo, Onintza, Ramos, José A.   +4 more
openaire   +3 more sources

Expression of the endocannabinoid receptors in human fascial tissue

European Journal of Histochemistry, 2016
Cannabinoid receptors have been localized in the central and peripheral nervous system as well as on cells of the immune system, but recent studies on animal tissue gave evidence for the presence of cannabinoid receptors in different types of tissues ...
C. Fede, G. Albertin, L. Petrelli, M.M. Sfriso, C. Biz, R. De Caro, C. Stecco   +6 more
doaj   +1 more source

Cannabinoid receptor 2 signal promotes type 2 immunity in the lung

Cell Insight, 2023
Type 2 immunity in the lung protects against pathogenic infection and facilitates tissue repair, but its dysregulation may lead to severe human diseases. Notably, cannabis usage for medical or recreational purposes has increased globally.
Tingting Liu, Jiaqi Liu, Hongjie Chen, Xin Zhou, Wei Fu, Ying Cao, Jing Yang   +6 more
doaj   +1 more source

Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma

BMC Cancer, 2018
Background The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprising the endocannabinoid system ...
Mohammed I. Khan, Anna A. Sobocińska, Klaudia K. Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M. Czarnecka, Cezary Szczylik   +7 more
doaj   +1 more source

Brain Cannabinoid CB2 Receptor in Schizophrenia

Biological Psychiatry, 2010
Neural endocannabinoid function appears to be involved in schizophrenia. Two endocannabinoid receptors, CB1 and CB2, are found in the brain and elsewhere in the body. We investigated roles of CB2 in schizophrenia.An association study was performed between tag single nucleotide polymorphisms (SNPs) in the CNR2 gene encoding the CB2 receptor and ...
Hiroki, Ishiguro, Yasue, Horiuchi, Maya, Ishikawa, Minori, Koga, Keiko, Imai, Yoshimi, Suzuki, Miyuki, Morikawa, Toshiya, Inada, Yuichiro, Watanabe, Makoto, Takahashi, Toshiyuki, Someya, Hiroshi, Ujike, Nakao, Iwata, Norio, Ozaki, Emmanuel S, Onaivi, Hiroshi, Kunugi, Tsukasa, Sasaki, Masanari, Itokawa, Makoto, Arai, Kazuhiro, Niizato, Shyuji, Iritani, Izumi, Naka, Jun, Ohashi, Akiyoshi, Kakita, Hitoshi, Takahashi, Hiroyuki, Nawa, Tadao, Arinami   +26 more
openaire   +3 more sources

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders

Pharmaceuticals, 2010
Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB2 receptor in the brain
Michelle Roche, David P Finn
doaj   +1 more source

The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. [PDF]

, 2010
Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p.Thr453Thr; rs1049353) single nucleotide ...
Brand, Stephan, Burkhard Göke, Göke, Burkhard, Storr, Martin, Göke Burkhard, Ochsenkühn, Thomas, Stephan Brand, Brand Stephan, Thomas Ochsenkühn, Storr Martin, Pfennig, Simone, Dominik Emmerdinger, Peter Lohse, Martin Storr, Emmerdinger Dominik, Diegelmann, Julia, Lohse, Peter, Simone Pfennig, Diegelmann Julia, Emmerdinger, Dominik, Julia Diegelmann, Ochsenkühn Thomas, Lohse Peter, Pfennig Simone   +23 more
core   +1 more source

Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis*

Journal of Lipid Research, 2008
Macrophage apoptosis is an important process in the pathophysiology of atherosclerosis. Oxidized low-density lipoproteins (OxLDL) are a major component of lesions and potently induce macrophage apoptosis.
Natalie E. Freeman-Anderson, Theresa G. Pickle, Courtney D. Netherland, Alicia Bales, Nancy E. Buckley, Douglas P. Thewke   +5 more
doaj   +1 more source

Cannabinoid CB₁ allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression. [PDF]

Br J Pharmacol
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Solomon ID, Garai S, Thakur GA, Hohmann AG.   +3 more
europepmc   +2 more sources