Results 51 to 60 of about 1,265,475 (213)

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Efeito anti-hiperalgésico e antiinflamatório de triterpenos pentacíclicos em modelos experimentais de hiperalgesia crônica: participação do sistema canabinóide [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente estudo revela que o tratamento oral com os triterpenos pentacíclicos betulina (30 mg/mg ...
Silva, Kathryn Ana Bortolini Simão da
core  

Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Molecules, 2022
Zebrafish (ZF; Danio rerio) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate (4F-MDMB-BINACA) in ZF larvae after ...
Yu Mi Park, Charlotte Dahlem, Markus R. Meyer, Alexandra K. Kiemer, Rolf Müller, Jennifer Herrmann   +5 more
doaj   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Protocol for crystal structure determination of the antagonist-bound human cannabinoid receptor CB2

STAR Protocols, 2021
Summary: Human cannabinoid receptor CB2 plays an important role in the immune system and is an attractive therapeutic target for pain and for inflammatory and neurodegenerative diseases.
Ling Shen, Xiaoting Li, Junlin Liu, Kaiwen Liu, Zhi-Jie Liu, Tian Hua   +5 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Structural insights into cannabinoid receptors CB1 and CB2: determinants of ligand selectivity

Frontiers in Chemical Biology
Cannabinoid receptors 1 (CB1) and 2 (CB2) are key components of the endocannabinoid system and play central roles in regulating diverse physiological processes, including neural signaling, immune modulation, and inflammation. Both receptors belong to the
Ann Varghese, Jie Liu, Wenjing Guo, Tucker A. Patterson, Huixiao Hong   +4 more
doaj   +1 more source

Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands

Molecular Pain, 2011
Background Both T-type calcium channels and cannabinoid receptors modulate signalling in the primary afferent pain pathway. Here, we investigate the analgesics activities of a series of novel cannabinoid receptor ligands with T-type calcium channel ...
You Haitao, Gadotti Vinicius M, Petrov Ravil R, Zamponi Gerald W, Diaz Philippe   +4 more
doaj   +1 more source

Cannabinoid receptor CB2 modulates axon guidance. [PDF]

PLoS ONE, 2013
Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff, Anteneh Argaw, Bruno Cecyre, Hosni Cherif, Nicolas Tea, Nawal Zabouri, Christian Casanova, Maurice Ptito, Jean-François Bouchard   +8 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source