Results 1 to 10 of about 80,881 (281)

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways [PDF]

BMC Cardiovascular Disorders, 2008
Background Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a ...
Edvinsson Lars, Gesslein Bodil, Wackenfors Angelica, Gustafsson Lotta, Nilsson David, Paulsson Per, Ingemansson Richard, Malmsjö Malin   +7 more
doaj   +5 more sources

Protein kinase C inhibition attenuates vascular ET_B receptor upregulation and decreases brain damage after cerebral ischemia in rat [PDF]

BMC Neuroscience, 2007
Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter, Stenman Emelie, Henriksson Marie, Edvinsson Lars   +3 more
doaj   +4 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

BMC Cancer, 2008
Background Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two ...
Patterson Paul H, Montgomery Jennifer P
doaj   +5 more sources

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension

Frontiers in Immunology, 2022
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling, Christoph Tabeling, Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Berthold Hocher, Berthold Hocher, Norbert Suttorp, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Elise Siegert, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Martin Witzenrath, Martin Witzenrath, Martin Witzenrath   +30 more
doaj   +3 more sources

Genetic interactions between neurofibromin and endothelin receptor B in mice. [PDF]

PLoS ONE, 2013
When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose.
Mugdha Deo, Jenny Li-Ying Huang, Catherine D Van Raamsdonk   +2 more
doaj   +1 more source

Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors. [PDF]

PLoS ONE, 2016
Injury to the eye or retina triggers Müller cells, the major glia cell of the retina, to dedifferentiate and proliferate. In some species they attain retinal progenitor properties and have the capacity to generate new neurons. The epidermal growth factor
Mohammad Harun-Or-Rashid, Dardan Konjusha, Caridad Galindo-Romero, Finn Hallböök   +3 more
doaj   +1 more source

Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar, Elizabeth M. Daugherty, Jeffrey O. Aceves, Randee Sedaka, Ijeoma E. Obi, J. Miller Allan, Reham H. Soliman, Chunhua Jin, Carmen De Miguel, Sarah H. Lindsey, Jennifer S. Pollock, David M. Pollock   +11 more
doaj   +1 more source

Endothelin B receptors contribute to retinal ganglion cell loss in a rat model of glaucoma. [PDF]

PLoS ONE, 2012
Glaucoma is an optic neuropathy, commonly associated with elevated intraocular pressure (IOP) characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells which could lead to loss of vision. Endothelin-1 (ET-1)
Alena Z Minton, Nitasha R Phatak, Dorota L Stankowska, Shaoqing He, Hai-Ying Ma, Brett H Mueller, Ming Jiang, Robert Luedtke, Shaohua Yang, Colby Brownlee, Raghu R Krishnamoorthy   +10 more
doaj   +1 more source

Stretching Promotes Wound Contraction Through Enhanced Expression of Endothelin Receptor B and TRPC3 in Fibroblasts

Plastic and Reconstructive Surgery, Global Open, 2023
Background:. One factor that can contribute to the development of hypertrophic scar contracture is mechanical stress. Mechanical cyclic stretch stimuli enhance the secretion of endothelin-1 (ET-1) from keratinocyte.
Kenichiro Kawai, MD, PhD, Hisako Ishise, MD, PhD, Tateki Kubo, MD, PhD, Barrett Larson, MD, Toshihiro Fujiwara, MD, PhD, Soh Nishimoto, MD, PhD, Masao Kakibuchi, MD, PhD   +6 more
doaj   +1 more source

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

BMC Cancer, 2018
Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed.
Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner, Koon-Chu Yaiw, Cecilia Söderberg-Naucler   +17 more
doaj   +1 more source