Results 101 to 110 of about 394,846 (264)
BMC Pulmonary Medicine, 2006 Background Smoking is known to cause chronic inflammatory changes in the bronchi and to contribute to airway hyper-reactivity, such as in bronchial asthma.
Vikman Petter +4 more
doaj +1 more source
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Journal of Biological Chemistry, 2001 To examine the potential regulatory involvement of retroelements in the human genome, we screened the transcribed sequences of GenBankTM and expressed sequence tag data bases with long terminal repeat (LTR) elements derived from different human ...
P. Medstrand, J. Landry, D. Mager
semanticscholar +1 more source
Evidence of Endothelin‐B Receptor Dysfunction in Obesity
The FASEB Journal, 2019 BackgroundThe endothelin system has been identified as a key regulator of vascular function and is comprised of two opposing receptors; a constricting A‐receptor (ETAR) and dilating B‐receptor (ETBR). Dysregulation of the ETBR and obesity both independently contribute to vascular endothelial dysfunction.
Ryan A. Harris +10 more
openaire +1 more source
Interdisciplinary Medicine, EarlyView.This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang +4 more
wiley +1 more source
Salt-sensitive hypertension in endothelin-B receptor-deficient rats.
Journal of Clinical Investigation, 2000 The role of the endothelin-B receptor (ET(B)) in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo.
C. Gariepy +4 more
semanticscholar +1 more source
Diffuse Melanosis Cutis Under Immuno‐ and Targeted Therapy
JEADV Clinical Practice, EarlyView.ABSTRACT In patients with highly advanced melanoma, rarely a diffuse melanosis cutis (DMC) can be noticed. Even though the condition is generally harmless itself, it can have a significant impact on the patient's well‐being as an obvious mark of the disease. DMC causes a grey or brown discoloration of the skin and mucous membranes. We report on a young
Christiane Cussigh +3 more
wiley +1 more source
Advances in Pharmacological Sciences, 2009 Ethanol-induced folate deficiency is due to effects of ethanol on folate metabolism and absorption. We have already shown by using different methods that ethanol interferes with reabsorption of folate from the proximal tubule. In this study, we have used
Sivakumar JT Gowder, Kenneth E. McMartin
doaj +1 more source
BMC Neuroscience, 2011 Background Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS ...
Cao Yong-Xiao +4 more
doaj +1 more source
Morroniside Improves Diabetic Osteoporosis via the AGE/RAGE/Wnt/β‐Catenin Signaling Pathway
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Morroniside has been shown to possess various pharmacological activities, including anti‐inflammatory and antioxidative effects. This study investigates the potential mechanisms by which morroniside ameliorates diabetic osteoporosis (DOP). In vivo experiments were conducted to evaluate biochemical parameters in rats under different treatment ...
Lu Yang +4 more
wiley +1 more source