Results 171 to 180 of about 394,846 (264)

Crosstalk Between Gastric Cancer and Adjacent Mucosa Reveals EDN1-EDNRA-Mediated Regulation of Cancer Stemness and Immunomodulation Networks. [PDF]

J Cell Mol Med
Zhu X, Zhang Y, Liao H, Hu J, Xiao X.
europepmc   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Dual ET_A-ET_B receptor antagonism improves metabolic syndrome-induced heart failure with preserved ejection fraction. [PDF]

Fundam Clin Pharmacol
Lockwood F, Lachaux M, Harouki N, Soulié M, Nicol L, Renet S, Dumesnil A, Vercauteren M, Bellien J, Iglarz M, Richard V, Mulder P.   +11 more
europepmc   +1 more source

Acid regulation of NaDC-1 requires a functional endothelin B receptor.

Kidney International, 2010
Liping Liu, M. Zacchia, Xuefei Tian, Laxiang Wan, A. Sakamoto, M. Yanagisawa, R. Alpern, P. Preisig   +7 more
semanticscholar   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress. [PDF]

Cureus
Abdelmissih S, Ahmed Rashed L, Sharif Ismail Negm M, Mohamed Sayed W, Mahmoud HM, Elmorsy S.   +5 more
europepmc   +1 more source

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source

Difference Analysis of N-Terminal B-Type Natriuretic Peptide, High-Sensitivity Troponin I, and Endothelin-1 Levels in Patients With Normotensive and Hypertensive Acute Heart Failure. [PDF]

Cardiol Res
Ilhami YR, Darwin E, Decroli E, Efrida E.   +3 more
europepmc   +1 more source

Rosiglitazone Attenuates Endothelin-1–Induced Vasoconstriction by Upregulating Endothelial Expression of Endothelin B Receptor

HYPERTENSION, 2010
Jianwei Tian, W. Wong, Xiaohui Tian, Peng Zhang, Yu Huang, Nanping Wang   +5 more
semanticscholar   +1 more source

Pathogenesis of Melasma Explained

International Journal of Dermatology, Volume 64, Issue 7, Page 1201-1212, July 2025.
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley   +1 more source