Crosstalk Between Gastric Cancer and Adjacent Mucosa Reveals EDN1-EDNRA-Mediated Regulation of Cancer Stemness and Immunomodulation Networks. [PDF]
Zhu X, Zhang Y, Liao H, Hu J, Xiao X.
europepmc +1 more source
Gαq signalling from endosomes: A new conundrum
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Dual ET<sub>A</sub>-ET<sub>B</sub> receptor antagonism improves metabolic syndrome-induced heart failure with preserved ejection fraction. [PDF]
Lockwood F+11 more
europepmc +1 more source
Acid regulation of NaDC-1 requires a functional endothelin B receptor.
Liping Liu+7 more
semanticscholar +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf+10 more
wiley +1 more source
Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress. [PDF]
Abdelmissih S+5 more
europepmc +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood+3 more
wiley +1 more source
Difference Analysis of N-Terminal B-Type Natriuretic Peptide, High-Sensitivity Troponin I, and Endothelin-1 Levels in Patients With Normotensive and Hypertensive Acute Heart Failure. [PDF]
Ilhami YR+3 more
europepmc +1 more source
Pathogenesis of Melasma Explained
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley +1 more source