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The Biomarker Galaxy: Big Endothelin-1 Joins the Expanding Universe of Heart Failure Prognostication. [PDF]
Korean Circ JCho DH.
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Endothelin receptor B in trabecular meshwork
Experimental Eye Research, 2007Endothelin-1 (ET-1), the most potent vasoconstrictor known to date, seems to be involved in the pathogenesis of primary open angle glaucoma. ET-1 was found in different tissues of the eye and in high concentrations in the aqueous humour. The effects of ET-1 are mediated by two receptors, ET-A receptor (ET-AR) and ET-B receptor (ET-BR), which are both ...
Rita, Rosenthal +6 more
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Endothelin-B receptors activate Gα13
American Journal of Physiology-Cell Physiology, 1999Endothelin (ET) receptors activate heterotrimeric G proteins that are members of the Gi, Gq, and Gsfamilies but may also activate members of other families such as Gα12/13. Gα13has multiple complex cellular effects that are similar to those of ET. We studied the ability of ET receptors to activate Gα13using an assay for G protein α-chain activation ...
K, Kitamura +5 more
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Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma
Journal of Clinical Pathology, 2015Background Endothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC).
Cook, N +4 more
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Myeloperoxidase upregulates endothelin receptor type B expression
Journal of Molecular and Cellular Cardiology, 2014Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme's suppression of nitric oxide (NO⋅)
Denise, Lau +7 more
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Posttranslational Modifications of Endothelin Receptor Type B
Trends in Cardiovascular Medicine, 1998Endothelin receptor type B (ETb) is one of the two ET receptor subtypes, both of which belong to the G protein-coupled receptor (GPCR) superfamily. The primary amino acid sequence of ETb, published in 1990, predicted potential posttranslational modifications of the receptor protein, and in the last couple of years, we and others presented direct ...
Y, Okamoto, H, Ninomiya, T, Masaki
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Endothelin and endothelin receptors A and B in the human testis
Anatomy and Embryology, 1999Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
S, Ergün +4 more
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