Results 11 to 20 of about 394,846 (264)

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

open access: yesClinical, Cosmetic and Investigational Dermatology, 2023
Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN   +5 more
doaj   +3 more sources

A novel role for myeloid endothelin-B receptors in hypertension [PDF]

open access: yesEuropean Heart Journal, 2019
Aims Hypertension is common. Recent data suggest that macrophages (Mφ) contribute to, and protect from, hypertension. Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor with additional pro-inflammatory properties.
A. Czopek   +14 more
semanticscholar   +8 more sources

Ligand-dependent Differences in the Internalization of Endothelin A and Endothelin B Receptor Heterodimers* [PDF]

open access: yesJournal of Biological Chemistry, 2004
Endothelin-1 (ET-1) is a potent vasoactive peptide that acts on endothelin A (ETA) and endothelin B (ETB) receptors. Although both receptor subtypes are co-expressed in numerous cells, little is known about their ability to form heterodimers.
B. Gregan   +7 more
semanticscholar   +4 more sources

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

open access: yesCardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +4 more sources

Localization of endothelin-1 and endothelin-receptors A and B in human epididymis [PDF]

open access: yesMolecular Human Reproduction, 1997
Expression of mRNA of endothelin-1 (ET-1) and its receptors, endothelin receptor A (ET-A) and endothelin receptor B (ET-B), in human epididymis was assessed by reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemistry was performed on longitudinal sections through whole normal human epididymides.
Süleyman Ergün   +3 more
openaire   +3 more sources

Clarifying Endothelin Type B Receptor Function [PDF]

open access: yesHypertension, 2006
Endothelin (ET) receptors have become the targets for the treatment of a variety of cardiovascular disorders and a mixed ET type A (ETA)/ET type B (ETB) receptor antagonist, bosentan, is currently being used to effectively treat pulmonary hypertension.
David M. Pollock, Markus P. Schneider
openaire   +3 more sources

Targeting of endothelin receptor‐B to the neural crest [PDF]

open access: yesgenesis, 2008
AbstractEndothelin receptor B (Ednrb) plays a critical role in the development of melanocytes and neurons and glia of the enteric nervous system. These distinct neural crest‐derived cell types express Ednrb and share the property of intercalating into tissues, such as the intestine whose muscle precursor cells also express Ednrb.
Noah R. Druckenbrod   +4 more
openaire   +3 more sources

Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat

open access: yesBMC Neuroscience, 2007
Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter   +3 more
doaj   +1 more source

Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia.

open access: yesJournal of the American Society of Nephrology, 2016
AKI is associated with high mortality rates and the development of CKD. Ischemia/reperfusion (IR) is an important cause of AKI. Unfortunately, there is no available pharmacologic approach to prevent or limit renal IR injury in common clinical practice ...
J. Barrera-Chimal   +6 more
semanticscholar   +1 more source

Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis

open access: yesFrontiers in Cellular Neuroscience, 2022
Endothelin-1 (ET-1), a secreted signaling peptide, is suggested to be involved in multiple actions in various tissues including the brain, but its role in amyotrophic lateral sclerosis (ALS) remains unknown.
Yingzhen Zhang   +7 more
doaj   +1 more source

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