Results 11 to 20 of about 42,145 (224)

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension

Frontiers in Immunology, 2022
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling, Christoph Tabeling, Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Berthold Hocher, Berthold Hocher, Norbert Suttorp, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Elise Siegert, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Martin Witzenrath, Martin Witzenrath, Martin Witzenrath   +30 more
doaj   +3 more sources

The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders [PDF]

Gastroenterology Review
The gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells.
Arjun Singh, Rajvir Singh
doaj   +2 more sources

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan [PDF]

Journal of International Medical Research
Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging.
Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai   +6 more
doaj   +2 more sources

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Clinical, Cosmetic and Investigational Dermatology, 2023
Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN, Miot HA, Grassi TF, Dias-Melício LA, Santos L, Espósito ACC   +5 more
doaj   +4 more sources

Generating CAR-macrophages to target endothelin B receptor-positive tumors [PDF]

Cancer Immunology, Immunotherapy
The endothelin axis is highly involved and overexpressed in many tumors, making it an interesting therapeutic target. However, except for strategies based on small molecule antagonists, this axis is poorly targeted by immunotherapy approaches.
Cyril Lherminier, Narciso Costa, Amaury Herbet, Marie Hautière, Aloïse Mabondzo, Jérémie Martinet, Didier Boquet   +6 more
doaj   +2 more sources

DNA methylation of the endothelin receptor B makes blue fish yellow [PDF]

Nature Communications
Animal pigmentation is essential for concealment and communication in nature. Though selection acts on the phenotypes of an organism, these traits are often resolved to genes that shape pigmentation in populations.
Wei Fang, Danielle Blakkan, Alexandra Byrne, Gail Lee, Roya Bashier, Russell D. Fernald, Sebastian G. Alvarado   +6 more
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Genetic interactions between neurofibromin and endothelin receptor B in mice. [PDF]

PLoS ONE, 2013
When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose.
Mugdha Deo, Jenny Li-Ying Huang, Catherine D Van Raamsdonk   +2 more
doaj   +1 more source

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

Cardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +3 more sources

Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors. [PDF]

PLoS ONE, 2016
Injury to the eye or retina triggers Müller cells, the major glia cell of the retina, to dedifferentiate and proliferate. In some species they attain retinal progenitor properties and have the capacity to generate new neurons. The epidermal growth factor
Mohammad Harun-Or-Rashid, Dardan Konjusha, Caridad Galindo-Romero, Finn Hallböök   +3 more
doaj   +1 more source

EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding [PDF]

Journal of Pharmacy and Pharmacology, 2011
AbstractBackground and objectiveThe magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ETA or ETB receptors can be limited by apparent compensation mediated by the unblocked receptor. While the mechanism underlying this functionally defined interaction, or ‘cross-talk’, is not clear, binding studies suggest an ...
Robert M, Rapoport, Mario, Zuccarello
openaire   +2 more sources