Results 221 to 230 of about 394,846 (264)
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Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma
Journal of Clinical Pathology, 2015BackgroundEndothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC).MethodsExpression of ET-1, ETAR, ETBR, vascular endothelial growth factor and microvessel density (MVD) was ...
N. Cook+4 more
semanticscholar +4 more sources
Endothelin and endothelin receptors A and B in the human testis [PDF]
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
Süleyman Ergün+4 more
openaire +2 more sources
Journal of Physiology, 2019
Polycystic ovary syndrome (PCOS) is a complex syndrome with cardiovascular risk factors, including obesity and insulin resistance. PCOS is also associated with high androgens, increases the risk of cardiovascular dysfunction in women.
C. Usselman+6 more
semanticscholar +1 more source
Polycystic ovary syndrome (PCOS) is a complex syndrome with cardiovascular risk factors, including obesity and insulin resistance. PCOS is also associated with high androgens, increases the risk of cardiovascular dysfunction in women.
C. Usselman+6 more
semanticscholar +1 more source
Endothelin receptor B in trabecular meshwork
Experimental Eye Research, 2007Endothelin-1 (ET-1), the most potent vasoconstrictor known to date, seems to be involved in the pathogenesis of primary open angle glaucoma. ET-1 was found in different tissues of the eye and in high concentrations in the aqueous humour. The effects of ET-1 are mediated by two receptors, ET-A receptor (ET-AR) and ET-B receptor (ET-BR), which are both ...
Rüdiger Zorn+7 more
openaire +3 more sources
Mutations of the endothelin-B receptor and endothelin-3 genes in Hirschsprung?s disease
Pediatric Surgery International, 1996The endothelin-B receptor gene (EDNRB) and the endothelin-3 gene (EDN3) have recently been recognized as susceptibility genes for Hirschsprung's disease (HD). Novel EDNRB mutations have been detected in non-syndromic HD patients with heterozygous forms, and homozygous mutations of the EDNRB or the EDN3 genes have been reported in HD patients associated
Takeshi Kusafuka, Prem Puri
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Thermostabilization of the Human Endothelin Type B Receptor
Journal of Molecular Biology, 2016The peptide hormone endothelin, produced by the vascular endothelium, is involved in several physiological functions, including maintenance of vascular tone and humoral homeostasis. Endothelin transmits signals through the endothelin receptor, a G-protein-coupled receptor.
Shoko Nishimura+4 more
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Posttranslational Modifications of Endothelin Receptor Type B
Trends in Cardiovascular Medicine, 1998Endothelin receptor type B (ETb) is one of the two ET receptor subtypes, both of which belong to the G protein-coupled receptor (GPCR) superfamily. The primary amino acid sequence of ETb, published in 1990, predicted potential posttranslational modifications of the receptor protein, and in the last couple of years, we and others presented direct ...
Tomoh Masaki+2 more
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The Journal of Pharmacology and Experimental Therapeutics, 1994
Endothelin (ET)-A and ET-B receptors have been reported to exist in the spinal cord but the roles of ET-A and ET-B receptors in the spinal cord are poorly understood. To gain a better understanding of the roles of ET-A and ET-B receptors in nociceptive information transmission in the spinal cord, this study evaluated the effects of ET-1, ET-3 ...
T, Yamamoto+3 more
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Endothelin (ET)-A and ET-B receptors have been reported to exist in the spinal cord but the roles of ET-A and ET-B receptors in the spinal cord are poorly understood. To gain a better understanding of the roles of ET-A and ET-B receptors in nociceptive information transmission in the spinal cord, this study evaluated the effects of ET-1, ET-3 ...
T, Yamamoto+3 more
openaire +2 more sources