Results 231 to 240 of about 394,846 (264)
Some of the next articles are maybe not open access.
Journal of Cardiovascular Pharmacology, 1998
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ETA receptor, whereas the effects mediated by the ETB receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may
Christian Schroeder +2 more
openaire +3 more sources
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ETA receptor, whereas the effects mediated by the ETB receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may
Christian Schroeder +2 more
openaire +3 more sources
Endothelin-B receptors activate Gα13
American Journal of Physiology-Cell Physiology, 1999Endothelin (ET) receptors activate heterotrimeric G proteins that are members of the Gi, Gq, and Gs families but may also activate members of other families such as Gα12/13. Gα13 has multiple complex cellular effects that are similar to those of ET. We studied the ability of ET receptors to activate Gα13 using an assay for G protein α-chain activation
R. Tyler Miller +5 more
openaire +3 more sources
Augmented expression of endothelin‐1, endothelin‐3 and the endothelin‐B receptor in breast carcinoma
Histopathology, 2000AimsEndothelins (ETs) are peptides expressed in many tumours which may stimulate angiogenesis and desmoplasia. Because ETs have not been extensively studied mammary neoplasia, we assessed ET protein and mRNA expression and receptor mRNA expression in normal and neoplastic breast tissues.Methods and resultsTissues from five normal breasts, six ...
Subrata Chakrabarti +2 more
openaire +3 more sources
Glucocorticoids Decrease Endothelin-A- and -B-Receptor Expression in the Kidney
Journal of Cardiovascular Pharmacology, 2000Glucocorticoids play an important role in circulatory homeostasis and in excess they cause hypertension. These corticosteroids affect the expression of many genes involved in blood pressure control including preproendothelin-1 (PPET-1), the precursor of endothelin-1 (ET-1), a potent vasoactive peptide.
Annie Villeneuve +2 more
openaire +3 more sources
Oncology Reports, 2004
Endothelin-1 (ET-1) is overexpressed in breast carcinomas and influences via its receptors (ETAR and ETBR) transformation, differentiation and growth processes in the human breast, but little is known about the ET expression in breast cancer precursors.
Christian Wülfing +7 more
openaire +3 more sources
Endothelin-1 (ET-1) is overexpressed in breast carcinomas and influences via its receptors (ETAR and ETBR) transformation, differentiation and growth processes in the human breast, but little is known about the ET expression in breast cancer precursors.
Christian Wülfing +7 more
openaire +3 more sources
Regulated interaction of endothelin B receptor with caveolin‐1 [PDF]
European Journal of Biochemistry, 2003 The peptide hormone endothelin transmits various signals through G protein‐coupled receptors, the endothelin type A (ETAR) and B (ETBR) receptors. Caveolae are specialized lipid rafts containing polymerized caveolins. We examined the interaction of ETBR with caveolin‐1, expressed in Sf9, COS‐1, and HEK293 cells, and its effects on the subcellular ...
Tomohiro Yamaguchi +3 more
openaire +2 more sources
Journal of Neurosurgery, 2011
OBJECT Delayed cerebral ischemia after subarachnoid hemorrhage (SAH) remains a major cause of death and disability. It has been hypothesized that cerebrovascular upregulation of vasoconstrictor receptors is a key step in the development of delayed ...
C. Larsen +3 more
semanticscholar +1 more source
OBJECT Delayed cerebral ischemia after subarachnoid hemorrhage (SAH) remains a major cause of death and disability. It has been hypothesized that cerebrovascular upregulation of vasoconstrictor receptors is a key step in the development of delayed ...
C. Larsen +3 more
semanticscholar +1 more source
Endothelium, 1997
The human type-B endothelin receptor (h-ETB) was cloned from human lung poly A+RNA and stably expressed in CHO cells. Endothelin (ET) receptor binding and stimulation of PI hydrolysis demonstrated that the cloned h-ETB receptor is functional and linked to intracellular signal transduction pathways in CHO cells.
W. J. Chiou +5 more
openaire +3 more sources
The human type-B endothelin receptor (h-ETB) was cloned from human lung poly A+RNA and stably expressed in CHO cells. Endothelin (ET) receptor binding and stimulation of PI hydrolysis demonstrated that the cloned h-ETB receptor is functional and linked to intracellular signal transduction pathways in CHO cells.
W. J. Chiou +5 more
openaire +3 more sources
A Transgenic Strategy for Analysis of the Function of the Endothelin-B-Receptor
Journal of Cardiovascular Pharmacology, 2000Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (ET) receptor knockouts has been complicated by the development of lethal phenotypes. In this paper, we present our strategy for examining endothelin-B- (ET(B)) receptor function in the context of other ...
David J. Webb +2 more
openaire +3 more sources
Endothelin and Endothelin A/B Receptors Are Increased after Ischaemic Acute Renal Failure
Nephron Experimental Nephrology, 2001<i>Background/Aims:</i> Endothelin (ET) has been implicated as an indirect mediator of injury following acute renal ischaemia (ARI). The purpose of this study was to localize and quantitate ET and ET<sub>A</sub> and ET<sub>B</sub> receptors following ARI. <i>Methods:</i> A model of ARI, well characterized
Forbes, JM +5 more
openaire +3 more sources