Results 241 to 250 of about 394,846 (264)

Myeloperoxidase upregulates endothelin receptor type B expression

Journal of Molecular and Cellular Cardiology, 2014
Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme's suppression of nitric oxide (NO⋅)
Stephan Baldus, Volker Rudolph, Thomas Streichert, Stefan Blankenberg, Tanja K. Rudolph, Denise Lau, Anna Klinke, Katalin Szöcs   +7 more
openaire   +3 more sources

[Role of endothelin-B receptors in the pulmonary circulation].

Nihon Kyobu Shikkan Gakkai zasshi, 1997
Endothelin-1 (ET-1) is a potent vasoactive peptide and is thought to play an important role in the regulation of vascular tone. ET-1 can both constrict blood vessels, via endothelin-A (ET-A) receptors in vascular smooth muscle cells, and dilate then via endothelin-B (ET-B) receptors in endothelial cells in the systemic circulation.
Masayoshi Saito, Toshiaki Tani, Atsuhiro Hayashi, Koichiro Tatsumi, Kazutoshi Sugito, Takayuki Kuriyama, Hidetoshi Igari, Yasunori Kasahara   +7 more
openaire   +3 more sources

Endothelin-A and -B receptors in human coronary arteries and veins

Regulatory Peptides, 1996
Using reverse transcriptase-polymerase chain reaction, products corresponding to mRNA encoding endothelin-A and -B (ETA and ETB) receptors were demonstrated in human coronary arteries and veins with intact endothelium and in endothelium-denuded human coronary arteries.
Ole Saetrum Opgaard, Mikael Adner, Lars Edvinsson, Leonor Cantera   +3 more
openaire   +3 more sources

Localization of the Endothelin-B Receptor Using a Transgenic Approach

Journal of Cardiovascular Pharmacology, 2004
The use of reporter genes such as beta-galactosidase and green fluorescent protein is a powerful molecular tool for the visualization of in-vivo gene expression. In this paper, we describe the generation of mice that possess a beta-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem ...
David J. Webb, Adele Gordon, Yuri Kotelevtsev, Myung Shin   +3 more
openaire   +3 more sources

Expression of Endothelin A- and B-receptors in Human Nasal Mucosa

Acta Oto-Laryngologica, 1999
Several studies have suggested an important role for the endothelin (ET) family of peptides in the vascular regulation of the nose. In addition, there is increasing evidence that ETs play a role in allergic airway inflammation. Endothelin is produced locally in the nose and mediates its effects via two distinct receptor subtypes, termed ET(A) and ET(B).
R. Uddman, Lars Edvinsson, Sebastian Möller, G Fernström, L O Cardell   +4 more
openaire   +2 more sources

Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.

AJP - Renal Physiology, 2006
Collecting duct (CD)-derived endothelin-1 (ET-1) inhibits renal Na reabsorption and its deficiency increases blood pressure (BP). The role of CD endothelin B (ETB) receptors in mediating these effects is unknown.
Yuqiang Ge, A. Bagnall, P. Stricklett, K. Strait, D. Webb, Y. Kotelevtsev, D. Kohan   +6 more
semanticscholar   +1 more source

Presence of Contractile Endothelin-A and Dilatory Endothelin-B Receptors in Human Cerebral Arteries

Neurosurgery, 1997
The aim of the present study was to elucidate the endothelin receptor subtypes responsible for the endothelin-induced vasomotor responses of human cerebral arteries.Human cerebral arteries with endothelium were mounted in in vitro tissue baths, and the vascular responses to endothelin-1 (ET-1) and sarafotoxin 6c (a selective ETB agonist) were studied ...
Lars Edvinsson, Mikael Adner, Torun Nilsson, Leonor Cantera   +3 more
openaire   +3 more sources

Endothelin-B Receptor-Mediated Suppression of Endothelial Apoptosis

Journal of Cardiovascular Pharmacology, 1998
Endothelin (ET)-1 is an endothelium-derived vasoconstrictor as well as a mitogen. We have recently described a novel role of ET-1 as a survival factor for rat endothelial cells from serum deprivation-induced apoptosis. The present study was designed to determine which receptor subtype (ETA or ETB) is responsible for and what intracellular mediators are
Masayoshi Shichiri, Yukio Hirata, Fumiaki Marumo   +2 more
openaire   +3 more sources

Role of endothelin b receptor signals in reactive astrocytes

Life Sciences, 1998
We investigated the involvement of endothelinB receptor signals in the activation of astrocytes in vitro and in vivo. Endothelin reversed the stellate morphology of astrocytes induced by several agents. Endothelin stimulates astrocytic stress fiber formation.
openaire   +3 more sources

Immunolocalization of Endothelin-B Receptor in Mouse Intestinal Tract

Journal of Cardiovascular Pharmacology, 2004
The endothelin-B (ETB) receptor is a G-protein-coupled receptor that binds endothelin ligands and is essential for the development of epidermal melanocytes and enteric neurons. Recent reports indicate that ETB is localized to nuclei in cardiac ventricular myocytes, although it has been thought that ETB is localized mainly on the plasma membrane.
Tsuyoshi Uchide, Jiexia Quan, Javier Adur, Satoshi Takizawa, Takaharu Kozakai, Kaname Saida   +5 more
openaire   +3 more sources