Results 21 to 30 of about 394,846 (264)

Endothelin ETB Receptor-Mediated Astrocytic Activation: Pathological Roles in Brain Disorders

International Journal of Molecular Sciences, 2021
In brain disorders, reactive astrocytes, which are characterized by hypertrophy of the cell body and proliferative properties, are commonly observed.
Y. Koyama
semanticscholar   +1 more source

Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.

AJP - Renal Physiology, 2016
Recent studies suggested a direct link between circadian rhythms and regulation of sodium excretion. Endothelin-1 (ET-1) regulates sodium balance by promoting natriuresis through the endothelin B receptor (ETB) in response to increased salt in the diet ...
Jermaine G. Johnston, Joshua S. Speed, Chunhua Jin, D. Pollock   +3 more
semanticscholar   +1 more source

Lysosomal traffic of liganded endothelin B receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003
The endothelin B receptor (ETB) is an endothelial cell receptor found in caveolae. Studies with GFP-tagged ETB have suggested that the protein is constitutively endocytosed and targeted to lysosomes where it is rapidly degraded. We report that iodinated endothelin-1 ligand (ET-1) is taken up by cells transfected with ETB and remains undegraded for at ...
To Ha Loi, Natasha Foster, Owe-Young R, Keith K. Stanley   +3 more
openaire   +3 more sources

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

BMC Cardiovascular Disorders, 2020
Background Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury.
Enyong Su, Linwei Zhao, Xiaohang Yang, Binbin Zhu, Yahui Liu, Wen Zhao, Xianpei Wang, Datun Qi, Lijie Zhu, Chuanyu Gao   +9 more
doaj   +1 more source

Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. [PDF]

PLoS ONE, 2011
The renal medullary endothelin (ET-1) system plays an important role in the control of sodium excretion and arterial pressure (AP) through the activation of renal medullary ET-B receptors.
Joshua S Speed, Eric M George, Marietta Arany, Kathy Cockrell, Joey P Granger   +4 more
doaj   +1 more source

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease

Haematologica, 2017
Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease.
B. Koehl, P. Nivoit, W. El Nemer, O. Lenoir, P. Hermand, Catia Pereira, V. Brousse, Lea Guyonnet, G. Ghinatti, M. Benkerrou, Y. Colin, C. Le Van Kim, P. Tharaux   +12 more
semanticscholar   +1 more source

Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma

Thoracic Cancer, 2020
Background The five‐year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis.
Feiran Wei, You Ge, Wei Li, Xuerong Wang, Baoan Chen   +4 more
doaj   +1 more source

Status epilepticus induces vasogenic edema via tumor necrosis factor-α/ endothelin-1-mediated two different pathways. [PDF]

PLoS ONE, 2013
Status epilepticus (SE) induces vasogenic edema in the piriform cortex with disruptions of the blood-brain barrier (BBB). However, the mechanisms of vasogenic edema formation following SE are still unknown.
Ji-Eun Kim, Hea Jin Ryu, Tae-Cheon Kang
doaj   +1 more source

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse [PDF]

British Journal of Pharmacology, 1997
This study was performed to clarify whether the endothelin (ET) receptor subtypes mediating two pharmacologically heterogeneous response to ETB receptor agonists in normal mice are the product(s) of a single ETB receptor gene. Vasodilator responses to sarafotoxin S6c (S6c) in the thoracic aorta and contractile responses to ET‐1 and IRL1620 in the ...
Sadao Kimura, Tadahiko Mizuguchi, Mariko Nishiyama, Masashi Yanagisawa, Hirokazu Tanaka, Toshihiro Saito, Yoshiaki Masuda, Kayoko Moroi, Damiane de Wit, Tomoh Masaki   +9 more
openaire   +3 more sources

Endothelin A Receptor Blockade and Endothelin B Receptor Blockade Improve Hypokalemic Nephropathy by Different Mechanisms [PDF]

Journal of the American Society of Nephrology, 2003
Hypokalemia causes renal tubulointerstitial injury with an elevation in renal endothelin-1 (ET-1). It was hypothesized that hypokalemic tubulointerstitial injury is ameliorated by the blockade of ET-A receptors (ETA), whereas ET-B receptor (ETB) antagonism may exacerbate the injury, because ETB is thought to mediate vasodilation.
Richard J. Johnson, Fumiki Yoshihara, Naomi Yasui, Yuhei Kawano, Shin-ichi Suga, Takeshi Horio, Kenji Kangawa   +6 more
openaire   +2 more sources