Endothelin ETB Receptor-Mediated Astrocytic Activation: Pathological Roles in Brain Disorders
In brain disorders, reactive astrocytes, which are characterized by hypertrophy of the cell body and proliferative properties, are commonly observed.
Y. Koyama
semanticscholar +1 more source
Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.
Recent studies suggested a direct link between circadian rhythms and regulation of sodium excretion. Endothelin-1 (ET-1) regulates sodium balance by promoting natriuresis through the endothelin B receptor (ETB) in response to increased salt in the diet ...
Jermaine G. Johnston+3 more
semanticscholar +1 more source
Lysosomal traffic of liganded endothelin B receptor
The endothelin B receptor (ETB) is an endothelial cell receptor found in caveolae. Studies with GFP-tagged ETB have suggested that the protein is constitutively endocytosed and targeted to lysosomes where it is rapidly degraded. We report that iodinated endothelin-1 ligand (ET-1) is taken up by cells transfected with ETB and remains undegraded for at ...
To Ha Loi+3 more
openaire +3 more sources
Background Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury.
Enyong Su+9 more
doaj +1 more source
Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. [PDF]
The renal medullary endothelin (ET-1) system plays an important role in the control of sodium excretion and arterial pressure (AP) through the activation of renal medullary ET-B receptors.
Joshua S Speed+4 more
doaj +1 more source
Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease.
B. Koehl+12 more
semanticscholar +1 more source
Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
Background The five‐year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis.
Feiran Wei+4 more
doaj +1 more source
Status epilepticus induces vasogenic edema via tumor necrosis factor-α/ endothelin-1-mediated two different pathways. [PDF]
Status epilepticus (SE) induces vasogenic edema in the piriform cortex with disruptions of the blood-brain barrier (BBB). However, the mechanisms of vasogenic edema formation following SE are still unknown.
Ji-Eun Kim, Hea Jin Ryu, Tae-Cheon Kang
doaj +1 more source
Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse [PDF]
This study was performed to clarify whether the endothelin (ET) receptor subtypes mediating two pharmacologically heterogeneous response to ETB receptor agonists in normal mice are the product(s) of a single ETB receptor gene. Vasodilator responses to sarafotoxin S6c (S6c) in the thoracic aorta and contractile responses to ET‐1 and IRL1620 in the ...
Sadao Kimura+9 more
openaire +3 more sources
Endothelin A Receptor Blockade and Endothelin B Receptor Blockade Improve Hypokalemic Nephropathy by Different Mechanisms [PDF]
Hypokalemia causes renal tubulointerstitial injury with an elevation in renal endothelin-1 (ET-1). It was hypothesized that hypokalemic tubulointerstitial injury is ameliorated by the blockade of ET-A receptors (ETA), whereas ET-B receptor (ETB) antagonism may exacerbate the injury, because ETB is thought to mediate vasodilation.
Richard J. Johnson+6 more
openaire +2 more sources