Results 41 to 50 of about 42,033 (115)

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells

BMC Cell Biology, 2009
Background Endothelin-1 (ET-1) is a potent vasoactive peptide, which induces vasoconstriction and proliferation in vascular smooth muscle cells (VSMCs) through activation of endothelin type A (ETA) and type B (ETB) receptors.
Edvinsson Lars, Chen Qing-wen, Xu Cang-Bao   +2 more
doaj   +1 more source

Gene expression of endothelin receptors in replaced rheumatic mitral stenotic valves Expressão gênica de receptores de endotelina em valvas mitrais reumáticas estenóticas substituídas

Brazilian Journal of Cardiovascular Surgery, 2012
OBJECTIVES: Rheumatic fever is a highly prevalent disease in Brazil, and it poses a major public health problem. It is the leading cause of acquired heart disease in childhood and adolescence.
Sydney Correia Leão, Fernanda Maria Silveira Souto, Ricardo Vieira da Costa, Thaisa de Fatima Almeida Rocha, Yolanda Galindo Pacheco, Tania Maria de Andrade Rodrigues   +5 more
doaj  

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Cellular Physiology and Biochemistry, 2017
Background/Aims: Studies have shown that a change in endothelin receptor expression in the artery is related to pregnancy-induced hypertension (PIH). However, the mechanism underlying this change remains unclear. Methods: To test whether the distribution
Yuan Sun, Xicheng Zhang, Zhaolei Chen, Miao Xu, Minghui Ou   +4 more
doaj   +1 more source

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

EMBO Molecular Medicine, 2017
Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations ...
Michael P Smith, Emily J Rowling, Zsofia Miskolczi, Jennifer Ferguson, Loredana Spoerri, Nikolas K Haass, Olivia Sloss, Sophie McEntegart, Imanol Arozarena, Alex von Kriegsheim, Javier Rodriguez, Holly Brunton, Jivko Kmarashev, Mitchell P Levesque, Reinhard Dummer, Dennie T Frederick, Miles C Andrews, Zachary A Cooper, Keith T Flaherty, Jennifer A Wargo, Claudia Wellbrock   +20 more
doaj   +1 more source

Cooperation of endothelin-1 signaling with melanosomes plays a role in developing and/or maintaining human skin hyperpigmentation

Biology Open, 2015
Skin hyperpigmentation is characterized by increased melanin synthesis and deposition that can cause significant psychosocial and psychological distress.
Daiki Murase, Akira Hachiya, Mamiko Kikuchi-Onoe, Rachel Fullenkamp, Atsushi Ohuchi, Takashi Kitahara, Shigeru Moriwaki, Tadashi Hase, Yoshinori Takema   +8 more
doaj   +1 more source

Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi

BMC Pulmonary Medicine, 2006
Background Smoking is known to cause chronic inflammatory changes in the bronchi and to contribute to airway hyper-reactivity, such as in bronchial asthma.
Vikman Petter, Nilsson Elisabeth, Xu Cang-Bao, Granström Bengt W, Edvinsson Lars   +4 more
doaj   +1 more source

Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ET_A receptors

BMC Neuroscience, 2011
Background Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS ...
Cao Yong-Xiao, Zhang Yaping, Xu Cang-Bao, Cao Lei, Edvinsson Lars   +4 more
doaj   +1 more source

Methods to Evaluate the Effect of Ethanol on the Folate Analogue: Fluorescein Methotrexate Uptake in Human Proximal Tubular Cells

Advances in Pharmacological Sciences, 2009
Ethanol-induced folate deficiency is due to effects of ethanol on folate metabolism and absorption. We have already shown by using different methods that ethanol interferes with reabsorption of folate from the proximal tubule. In this study, we have used
Sivakumar JT Gowder, Kenneth E. McMartin
doaj   +1 more source

A review of pulmonary arterial hypertension: role of ambrisentan

Vascular Health and Risk Management, 2007
Robyn J BarstColumbia University College of Physicians & Surgeons, New York, NY, USAAbstract: Pulmonary arterial hypertension (PAH) is a rare fatal disease.
Robyn J Barst
doaj  

Endothelin-1- and acetylcholine-mediated effects in human and rat vessels: impact of perivascular adipose tissue, diabetes, angiotensin II, and chemerin

Blood Pressure
Objective To study the role of perivascular adipose tissue (PVAT) in the reactivity of rat and human vessels.Methods Iliac and mesenteric arteries were obtained from normotensive Sprague-Dawley rats, hypertensive transgenic (mRen2)27 rats overexpressing ...
Edwyn O. Cruz-López, Lunbo Tan, Daniël G. Stolk, Antoon J. van den Bogaerdt, Koen Verdonk, A. H. Jan Danser   +5 more
doaj   +1 more source