Results 41 to 50 of about 394,846 (264)

Ovarian hormones modulate endothelin A and B receptor expression [PDF]

open access: yesLife Sciences, 2016
The study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues.Female Sprague-Dawley rats were subjected to bilateral ovariectomy and divided into four groups ovariectomized (OVX), OVX+E2, OVX+P, and OVX+E2+P.
Eman Y. Gohar   +2 more
openaire   +3 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor

open access: yesBMC Cancer, 2008
Background Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two ...
Patterson Paul H, Montgomery Jennifer P
doaj   +1 more source

Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage

open access: yesScientific Reports, 2022
We have previously shown that Kyoto University Substances (KUSs), valosin-containing protein (VCP) modulators, suppress cell death in retinal ganglion cells of glaucoma mouse models through alterations of various genes expressions.
Mami Kusaka   +6 more
doaj   +1 more source

Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity

open access: yesFrontiers in Genetics, 2016
The membrane bound melanocortin 1 receptor (MC1R), and the endothelin B receptor (ENDBR) are two G-protein coupled receptors that play important roles in constitutive regulation of melanocytes and their response to ultraviolet radiation (UVR), the main ...
V. Swope, Z. Abdel‐Malek
semanticscholar   +1 more source

Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. [PDF]

open access: yesPLoS ONE, 2012
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and ...
John Gatfield   +4 more
doaj   +1 more source

Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease

open access: yesBMC Cardiovascular Disorders, 2009
Background Endothelin-1 and angiotensin II are strong vasoconstrictors. Patients with ischemic heart disease have elevated plasma levels of endothelin-1 and angiotensin II and show increased vascular tone.
Malmsjö Malin   +5 more
doaj   +1 more source

Collecting duct-specific endothelin B receptor knockout increases ENaC activity.

open access: yesAmerican Journal of Physiology - Cell Physiology, 2012
Collecting duct (CD)-derived endothelin-1 (ET-1) acting via endothelin B (ETB) receptors promotes Na(+) excretion. Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure. Activity of the epithelial Na(+)
V. Bugaj   +3 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Loss of renal medullary endothelin B receptor function during salt deprivation is regulated by angiotensin II.

open access: yesAJP - Renal Physiology, 2012
We have recently demonstrated that chronic infusion of exogenous ANG II, which induces blood pressure elevation, attenuates renal medullary endothelin B (ET(B)) receptor function in rats.
W. Kittikulsuth, J. Pollock, D. Pollock
semanticscholar   +1 more source

Evidence for Downregulation of the Endothelin-B-Receptor By the Use of Fluorescent Endothelin-1 and a Fusion Protein Consisting of the Endothelin-B-Receptor and the Green Fluorescent Protein

open access: yesJournal of Cardiovascular Pharmacology, 2000
We generated fusion proteins consisting of the endothelin-B (ET(B))-receptor and the enhanced green fluorescent protein (EGFP) to visualize receptor internalization. In Madin Darby canine kidney (MDCK) clones expressing ET(B)/EGFP fusion proteins, single class high affinity binding sites for [125I]endothelin-1 (ET-1) were found (for two different ...
Alexander Oksche   +7 more
openaire   +4 more sources

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