Results 41 to 50 of about 394,846 (264)

Ovarian hormones modulate endothelin A and B receptor expression [PDF]

Life Sciences, 2016
The study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues.Female Sprague-Dawley rats were subjected to bilateral ovariectomy and divided into four groups ovariectomized (OVX), OVX+E2, OVX+P, and OVX+E2+P.
Eman Y. Gohar, Choudhury Yusuf, David M. Pollock   +2 more
openaire   +3 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor

BMC Cancer, 2008
Background Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two ...
Patterson Paul H, Montgomery Jennifer P
doaj   +1 more source

Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage

Scientific Reports, 2022
We have previously shown that Kyoto University Substances (KUSs), valosin-containing protein (VCP) modulators, suppress cell death in retinal ganglion cells of glaucoma mouse models through alterations of various genes expressions.
Mami Kusaka, Tomoko Hasegawa, Hanako Ohashi Ikeda, Yumi Inoue, Sachiko Iwai, Kei Iida, Akitaka Tsujikawa   +6 more
doaj   +1 more source

Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity

Frontiers in Genetics, 2016
The membrane bound melanocortin 1 receptor (MC1R), and the endothelin B receptor (ENDBR) are two G-protein coupled receptors that play important roles in constitutive regulation of melanocytes and their response to ultraviolet radiation (UVR), the main ...
V. Swope, Z. Abdel‐Malek
semanticscholar   +1 more source

Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. [PDF]

PLoS ONE, 2012
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and ...
John Gatfield, Celia Mueller Grandjean, Thomas Sasse, Martine Clozel, Oliver Nayler   +4 more
doaj   +1 more source

Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease

BMC Cardiovascular Disorders, 2009
Background Endothelin-1 and angiotensin II are strong vasoconstrictors. Patients with ischemic heart disease have elevated plasma levels of endothelin-1 and angiotensin II and show increased vascular tone.
Malmsjö Malin, Chen Qingwen, Edvinsson Marie-Louise, Dimitrijevic Ivan, Kimblad Per-Ola, Edvinsson Lars   +5 more
doaj   +1 more source

Collecting duct-specific endothelin B receptor knockout increases ENaC activity.

American Journal of Physiology - Cell Physiology, 2012
Collecting duct (CD)-derived endothelin-1 (ET-1) acting via endothelin B (ETB) receptors promotes Na(+) excretion. Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure. Activity of the epithelial Na(+)
V. Bugaj, Elena V. Mironova, D. Kohan, J. Stockand   +3 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Loss of renal medullary endothelin B receptor function during salt deprivation is regulated by angiotensin II.

AJP - Renal Physiology, 2012
We have recently demonstrated that chronic infusion of exogenous ANG II, which induces blood pressure elevation, attenuates renal medullary endothelin B (ET(B)) receptor function in rats.
W. Kittikulsuth, J. Pollock, D. Pollock
semanticscholar   +1 more source

Evidence for Downregulation of the Endothelin-B-Receptor By the Use of Fluorescent Endothelin-1 and a Fusion Protein Consisting of the Endothelin-B-Receptor and the Green Fluorescent Protein

Journal of Cardiovascular Pharmacology, 2000
We generated fusion proteins consisting of the endothelin-B (ET(B))-receptor and the enhanced green fluorescent protein (EGFP) to visualize receptor internalization. In Madin Darby canine kidney (MDCK) clones expressing ET(B)/EGFP fusion proteins, single class high affinity binding sites for [125I]endothelin-1 (ET-1) were found (for two different ...
Alexander Oksche, Michael Beyermann, Gregor Boese, Gisela Papsdorf, Angelika Horstmeyer, Walter Rosenthal, Michael Bienert, Jens Furkert   +7 more
openaire   +4 more sources