Results 111 to 120 of about 35,242,900 (287)

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation [PDF]

, 2009
Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1).
Martin J Connock, Adi, Yaser, Sue Bayliss, Connock, Martin J, Yaser Adi, Moore, David J, Connock, Martin, Bayliss Sue, Adi Yaser, Connock Martin J, Moore David J, Bayliss, Sue, Moore, David; id_orcid, Yaser, A, Moore, David J., Dr., Connock, M., Adi, Y., Bayliss, Susan; id_orcid, David J Moore   +18 more
core   +3 more sources

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Frontiers in Endocrinology
Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH ...
Kevin C. J. Yuen, Rikke Hjortebjerg, Rikke Hjortebjerg, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, David R. Clemmons, Jan Frystyk, Jan Frystyk   +9 more
doaj   +1 more source

Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

Respiratory Research, 2005
Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François, Bonora Monique, Holzenberger Martin, Epaud Ralph, Ahamed Karmene, Puard Julien, Clement Annick, Henrion-Caude Alexandra   +7 more
doaj   +1 more source

Notiziario IGF n.19

, 2013
1) Editoriale del Segretario IGF;2) Verbale dell'Assemblea Annuale dei Soci 2007;3) Verbali dei Consigli di Presidenza;4) Cariche sociali biennio 2007-2009;5) Resoconti delle attività TC-ESIS nel 2007;6) Summer School IGF 2008;7) Convocazione Assemblea ...
Iacoviello, Francesco; Segretario IGF
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Role of Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development

Biomedicines
Cancer remains a significant global health concern, with lung cancer consistently leading as one of the most common malignancies. Genetic aberrations involving receptor tyrosine kinases (RTKs) are known to be associated with cancer initiation and ...
Ayaz Shahid, Shaira Gail Santos, Carol Lin, Ying Huang   +3 more
doaj   +1 more source

Understanding the key to targeting the IGF axis in cancer: a biomarker assessment

Frontiers in Oncology, 2015
Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this failed to translate to patient benefit in Phase 2/3 trails in unselected patients. This was further complicated by the
Kunal Amratlal Lodhia, Piyawan eTienchaiananda, Paul eHaluska   +2 more
doaj   +1 more source

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Paul J. Declerck, Rehberg, Markus, Daniel Puhr-Westerheide, Lerchenberger, Max, Uhl, Bernd, Kanse, Sandip, Johanna Liebl, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Zahler, Stefan, Lorenzl, Stefan, Elisabeth Deindl, Khandoga, Andrej, Declerck, Paul J., Stefan Zahler, Schmalix, Wolfgang, Fritz Krombach, Liebl, Johanna, Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Andrej Khandoga, Stefan Lorenzl, Deindl, Elisabeth, Wolfgang Schmalix, Puhr-Westerheide, Daniel, Sandip Kanse   +27 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source