Results 91 to 100 of about 89,239 (242)

Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

Respiratory Research, 2005
Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François, Bonora Monique, Holzenberger Martin, Epaud Ralph, Ahamed Karmene, Puard Julien, Clement Annick, Henrion-Caude Alexandra   +7 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Role of Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development

Biomedicines
Cancer remains a significant global health concern, with lung cancer consistently leading as one of the most common malignancies. Genetic aberrations involving receptor tyrosine kinases (RTKs) are known to be associated with cancer initiation and ...
Ayaz Shahid, Shaira Gail Santos, Carol Lin, Ying Huang   +3 more
doaj   +1 more source

Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2009
Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model of IGF-IR overexpression in the lung has not been created.
Nicolle M. Linnerth, Megan D. Siwicky, Craig I. Campbell, Katrina L.M. Watson, James J. Petrik, Jeffrey A. Whitsett, Roger A. Moorehead   +6 more
doaj   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli, Viktor Milkevych, Jette Feveile Young, Martin Krøyer Rasmussen   +3 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Detection of the GH Analogue Redalsomatropin Alfa in Sports Drug Testing: Immunological Approaches and LC‐HRMS/MS

Drug Testing and Analysis, EarlyView.
After evaluating the compatibility of the GH analogue redalsomatropin alfa with approved doping control immunoassays for rhGH, it was implemented into the existing detection method for somatrogon employing affinity purification with GHR‐Fc‐conjugated magnetic beads, tryptic digestion, and LC‐HRMS/MS to allow for a specific and sensitive detection ...
Katja Walpurgis, Andreas Thomas, Jasmin Thelen, Bettina Majer, Maneera Al‐Jaber, Wadha Abushareeda, Mario Thevis   +6 more
wiley   +1 more source