Results 81 to 90 of about 35,242,900 (287)

Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2010
Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell ...
Xueyan ZHANG, Jiuxian FENG, Huifang SHA, Jinsu HUANG, Baohui HAN   +4 more
doaj  

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling

Experimental and Molecular Medicine, 2023
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 ...
Hye-Jin Boo, Hye-Young Min, Su Jung Hwang, Hyo-Jong Lee, Jae-Won Lee, Sei-Ryang Oh, Choon-Sik Park, Jong-Sook Park, You Mie Lee, Ho-Young Lee   +9 more
doaj   +1 more source

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme [PDF]

, 2012
Background: Low muscle mass and function have been associated with poorer indicators of physical capability in olderpeople, which are in-turn associated with increased mortality rates.
Kumari, Meena, Hardy, R, John M. Starr (107707), Cooper, R, Gunnell, David, Rachel Cooper, Alfred Tamuno, Alfred, T, Kuh, D., Kumari Meena, Yoav Ben-Shlomo, Tom R Gaunt, Meena Kumari (95278), Kumari, M, Gaunt, Tom R., Cooper Cyrus, Martin, RM, Hardy, R., Team, HS, Sayer Avan Aihie, John M Starr, Day, I.N.M., Ben-Shlomo, Yoav, Ian J. Deary (107724), Tamuno Alfred, Harris, Sarah E, Sayer, AA, Sarah E Harris, Ian N M Day, Ian J Deary, HALCyon Study Team, The HALCyon study team, Gaunt Tom R., Richard M. Martin (176602), Kuh, Diana, Rebecca Hardy (188906), Deary, Ian J, Day, Ian N. M., Martin Richard M., Alfred, Tamuno, Richard M Martin, Yoav Ben-Shlomo (95286), Cooper, C., Diana Kuh, Ben-Shlomo, Y., Starr John M., Deary Ian J., Cooper, C, Martin, R.M., Starr, J.M., Day, IN, Rachel Cooper (188902), David Gunnell, Gaunt, TR, David Gunnell (41947), Harris Sarah E., Kuh Diana, Kumari, M., Gunnell, D, Craig, Leone, Gunnell David, Starr, John M., The HALCyon study team,, Starr, John M, Meena Kumari, Ben-Shlomo, Y, Cyrus Cooper (141250), Cooper, R., Martin, Richard M, Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, Starr, JM, Harris, SE, ?, ?, Alfred, T., Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Gunnell, D., Cooper Rachel, Ian N. M. Day (95288), Avan Aihie Sayer (188916), Rebecca Hardy, Hardy Rebecca, Deary, Ian J., Martin, Richard M., Harris, Sarah E., Day Ian N. M., Cooper, Cyrus, Day, INM, Sayer, Avan Aihie, Tom R. Gaunt (95274), Day, Ian N M, Gaunt, Tom R, Tamuno Alfred (188897), Kuh, D, Gaunt, T.R., Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923)   +101 more
core   +1 more source

The Influence of Field‐Assisted Sintering Technology (FAST) Temperature and Cooling Rate on the Microstructural Evolution in Gamma‐Titanium Aluminide Alloy GE4822

Advanced Engineering Materials, EarlyView.
Controlling the Field Assisted Sintering Technology (FAST) parameters, dwell temperature and cooling rate, significantly influences the microstructural evolution in titanium aluminide GE4822. Significant γ‐lamellar colonies develop only upon cooling through the α‐transus.
Jack Krohn, James Pepper, Martin Jackson
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

PLoS ONE, 2016
Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation.
Marc A Becker, Yasir H Ibrahim, Annabell S Oh, Dedra H Fagan, Sara A Byron, Aaron L Sarver, Adrian V Lee, Leslie M Shaw, Cheng Fan, Charles M Perou, Douglas Yee   +10 more
doaj   +1 more source