Results 81 to 90 of about 156,997 (300)

Obesity and cancer: existing and new hypotheses for a causal connection [PDF]

, 2018
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail, McPherson, Megan, Stone, Trevor W.   +2 more
core   +2 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

A Twenty-First Century Cancer Epidemic Caused by Obesity: The Involvement of Insulin, Diabetes, and Insulin-Like Growth Factors

International Journal of Endocrinology, 2013
Obesity has reached epidemic proportions in the developed world. The progression from obesity to diabetes mellitus type 2, via metabolic syndrome, is recognised, and the significant associated increase in the risk of major human cancers acknowledged.
Rosalyne L. Westley, Felicity E. B. May
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2010
Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell ...
Xueyan ZHANG, Jiuxian FENG, Huifang SHA, Jinsu HUANG, Baohui HAN   +4 more
doaj  

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling

Experimental and Molecular Medicine, 2023
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 ...
Hye-Jin Boo, Hye-Young Min, Su Jung Hwang, Hyo-Jong Lee, Jae-Won Lee, Sei-Ryang Oh, Choon-Sik Park, Jong-Sook Park, You Mie Lee, Ho-Young Lee   +9 more
doaj   +1 more source

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. [PDF]

, 2017
Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and ...
A Fantozzi, A Sica, Ainhoa Mielgo, Almudena Santos, B Ruffell, B Weigelt, BA Pulaski, BP Schneider, BZ Qian, C Marquette, Carlos Figueiredo, CD Mills, CJ Aslakson, CT Guy, CX Ma, D Ohlund, Dean Hammond, DF Quail, DF Quail, DG DeNardo, DH Fagan, DL Dexter, EA Rakha, EM Fox, EY Lin, F Klemm, Fiona Campbell, HA Wahba, JB Wyckoff, JE Maglione, JFR Robertson, JL Gooch, K Friedbichler, KA Lodhia, KM Bussard, KR Bauer, L Bingle, L Ireland, Lesley G. Ellies, Lucy Ireland, M Augsten, M Guha, M Pollak, MC Schmid, Michael Schmid, MJ Campbell, OC Olson, PJ Murray, RD Leek, RL Jones, RL Siegel, S Massarweh, SA Davie, SK Denduluri, SM Farabaugh, SR Nielsen, T Shree, TD Schmittgen, Thomas Bogenrieder, Ulrike Weyer-Czernilofsky, V Bronte, WJ Gradishar, XHF Zhang, Y Mao, YH Lu, YH Zhang, YW Wan   +66 more
core   +2 more sources

Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells

Biochemical and Biophysical Research Communications, 2007
Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expressing relatively high (MDA-MB-468)
Riedemann, J, Sohail, M, Macaulay, V
openaire   +3 more sources

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Gene polymorphisms in primary biliary cirrhosis: association with the disease and hepatic osteopathy [PDF]

, 2007
Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC). Estrogen receptor-alpha gene (ER- ), vitamin-D-receptor gene (VDR) and IL-1-receptor-antagonist gene (IL-1RN) are all ...
Bajnok, Éva, Ferenci, Péter, Lakatos, Péter, Lakatos, Péter László, Szalay, Ferenc, Takács, István, Willheim-Polli, Claudia   +6 more
core