Results 61 to 70 of about 156,997 (300)

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Andress, Andress, Arai, Arai, Beattie, Bramani, Carrick, Chernausek, David J. Flint, Elizabeth Tonner, Firth, Galanis, Gordon J. Allan, Headey, Ho, Huhtala, Hwa, Iain F. Gow, Imai, James Beattie, John H. Shand, Kalus, Kirsten Phillips, Malgorzata Szymanowska, Nam, Nam, Parker, Parker, Payet, Phillips, Provencher, Roger A. Clegg, Schneider, Shand, Sharon M. Kelly, Song, Song, Vorwerk, Wang, Whitmore, Yan   +40 more
core   +1 more source

Influence of Test Temperature and Test Frequency on Fatigue Life of Aluminum Alloy EN AW‐2618A

Advanced Engineering Materials, EarlyView.
The influence of test temperature and test frequency on the fatigue life of EN AW‐2618A is investigated. High‐cycle fatigue tests are performed at different test temperatures and frequencies on the 1000 h/230°C overaged state. Both test parameters reduce fatigue life due to time‐dependent damage mechanisms.
Ying Han, Julian M. Rosalie, Jan Radners, Mauro Madia, Philipp von Hartrott, Birgit Skrotzki   +5 more
wiley   +1 more source

IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA

Cell Death and Disease, 2021
The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated in physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when the heart is damaged to ...
Sangmi Ock, Woojin Ham, Chae Won Kang, Hyun Kang, Wang Soo Lee, Jaetaek Kim   +5 more
doaj   +1 more source

Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord

Journal of Bone Oncology, 2023
Background: Bone cancer pain (BCP) is one of the most ubiquitous and refractory symptoms of cancer patients that needs to be urgently addressed. Substantial studies have revealed the pivotal role of Cav3.2 T-type calcium channels in chronic pain, however,
Qingying Liu, Zhongyuan Lu, Huan Ren, Lijun Fu, Yueliang Wang, Huilian Bu, Minyu Ma, Letian Ma, Chen Huang, Jian Wang, Weidong Zang, Jing Cao, Xiaochong Fan   +12 more
doaj   +1 more source

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]

, 2016
Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Aplin, JD, Charnock, Jayne, Crocker, IP, Dilworth, MR, Sibley, CP, Westwood, M   +5 more
core   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Insulin-Like Growth Factor Receptor Signaling is Necessary for Epidermal Growth Factor Mediated Proliferation of SVZ Neural Precursors Following Neonatal Hypoxia-Ischemia

Frontiers in Neurology, 2014
In this study we assessed the importance of insulin-like growth factor (IGF) and epidermal growth factor (EGF) receptor co-signaling for rat neural precursor (NP) cell proliferation and self-renewal in the context of a developmental brain injury that is ...
Dhivyaa eAlagappan, Amber N. Ziegler, Shravanthi eChidambaram, Jungsoo eMin, Teresa L. Wood, Steven W. Levison   +5 more
doaj   +1 more source

Effects of adipokine administration to the hypothalamic preoptic area on body temperature in rats

Journal of Pharmacological Sciences, 2020
The effects of adipokine administration to the hypothalamic preoptic area (POA), which is one of the body temperature (BT) regulation centers in the central nervous system, on BT were investigated in male Wistar rats.
Hiromi Tsushima, Kazuyo Yamada
doaj   +1 more source

牛尾椎椎間板におけるインスリン様成長因子-1(IGF-1)の自己分泌機構及びIGF-1が椎間板のプロテオグリカン合成に与える影響 [PDF]

, 1996
The present study was undertaken to investigate the effect of IGF-1 on proteoglycan (PG) synthesis and the autocrine/paracrine mechanisms involving insulin-like growth factor-1 (IGF-1) in the bovine coccygeal intervertebral disc.IGF-1 stimulated PG ...
Osada Ryusuke
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source