Results 111 to 120 of about 3,525,166 (333)

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H., Al-Qassab, H., Ashford, M.L.J., Ashford, M.L.J., Barsh, G.S., Barsh, G.S., Batterham, R.L., Batterham, R.L., Bedford, D.C., Bedford, D.C., Bell, J.D., Bell, J.D., Choudhury, A.I., Choudhury, A.I., Claret, M., Claret, M., Clements, M., Clements, M., Diakonov, I., Diakonov, I., Heffron, H., Heffron, H., Hisadome, K., Hisadome, K., MacColl, G., MacColl, G., Moosajee, V., Moosajee, V., Selman, C., Selman, C., Simmgen, M., Simmgen, M., Smith, M.A., Smith, M.A., Speakman, J.R., Speakman, J.R., Withers, D.J., Withers, D.J., Xu, A.W., Xu, A.W.   +39 more
core   +4 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

A model for insulin binding to the insulin receptor [PDF]

European Journal of Biochemistry, 1994
The affinities of a number of insulin analogues for the human insulin receptor, a truncated soluble form of the insulin receptor, and the human insulin‐like growth factor 1 receptor were determined. Insulin analogues with substitutions in the A13 or B17 positions were shown to have anomalous binding properties. This suggests that these positions, which
openaire   +3 more sources

Adipocytes, aldosterone and obesity-related hypertension [PDF]

, 2016
Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions.
Friederich-Persson, Malou, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M., White, Anna   +3 more
core   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis [PDF]

, 2003
Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging contrast agents or in drug delivery applications.
Berry, C.C., Curtis, A.S.G., Gupta, A.K., Gupta, M.   +3 more
core   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

The Insulin/IGF system in colorectal cancer development and resistance to therapy

Frontiers in Oncology, 2015
The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri, Elena eTirrò, Maria Stella ePennisi, Michele eMassimino, Stefania eStella, Chiara eRomano, Livia eManzella   +6 more
doaj   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Aubert, Busetto, Butz, Christopher J. Kenyon, Contreras, Cowley, De la Sieera, Folli, Frederich, Hiroaki Masuzaki, Hiroshi Shinyama, Hiroshi Yamamoto, Janice M. Paterson, Jeffrey S. Flier, Joel K. Elmquist, John J. Mullins, Johnson, Jonathan R. Seckl, Kopelman, Lalouel, Llorens-Cortes, Massiera, Masuzaki, Matthew G.F. Sharp, Miller, Mills, Montani, Morton, Nicholas M. Morton, O’Brien, Pradevand, Pratt, Rotimi, Stepp, Stewart Fleming, Villiquette, Walker, Weinburger, Williams, Yamamoto   +39 more
core   +5 more sources