Biochemical and cellular properties of insulin receptor signalling
Nature Reviews Molecular Cell Biology, 2017 The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action ...
Timothy E McGraw +2 more
exaly +2 more sources
The signalling conformation of the insulin receptor ectodomain
Nature Communications, 2018 The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete.
Felix Weis +10 more
doaj +2 more sources
Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands S961 and Ins-AC-S2 [PDF]
Nature CommunicationsCongenital hyperinsulinism is a rare genetic disease characterized by overproduction of insulin. One class of potential treatments is insulin receptor antagonists like S961 and Ins-AC-S2, which comprise segments for binding each of the two insulin ...
Amber Vogel +5 more
doaj +2 more sources
Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. [PDF]
PLoS ONE, 2009 BACKGROUND:The insulin receptor is localized in caveolae and is dependent on caveolae or cholesterol for signaling in adipocytes. When stimulated with insulin, the receptor is internalized.
Siri Fagerholm +4 more
doaj +1 more source
Insulin receptor-inspired soluble insulin binder
European Journal of Cell Biology, 2023 The insulin receptor (IR) is a 320 kDa membrane receptor tyrosine kinase mediating the pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates including serine/threonine-protein kinase (AKT1), and IR ...
Christopher Mendoza +6 more
doaj +1 more source
Insulin-Responsive Transcription Factors
Biomolecules, 2021 The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic β-cells, and in some areas of the central nervous system ...
Gerald Thiel +2 more
doaj +1 more source
Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much ...
Tine Glendorf +7 more
doaj +1 more source
Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor
Bio-Protocol, 2023 Far-western blotting, derived from the western blot, has been used to detect interactions between proteins in vitro, such as receptor–ligand interactions.
Jinghua Peng +3 more
doaj +1 more source
Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
The Journal of Headache and Pain, 2022 Background Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent ...
Judit Rosta +5 more
doaj +1 more source
ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES [PDF]
Biotechnologia Acta, 2014 The insulin receptor was isolated from the liver cell membranes of control and diabetic rats. The protein purity was controlled by electrophoresis and Western blot.
T. I. Halenova +3 more
doaj +1 more source