Results 41 to 50 of about 502,774 (317)

The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins

Frontiers in Endocrinology, 2015
Insulin-like peptides, such as insulin and insulin-like growth factors (IGFs), induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism and decreased catabolism in many cell types and in vivo.
Fumihiko eHakuno, Toshiaki eFukushima, Toshiaki eFukushima, Yosuke eYoneyama, Hiroyasu eKamei, Atsufumi eOzoe, Hidehito eYoshihara, Daisuke eYamanaka, Takashi eShibano, Meri eSone-Yonezawa, Bu-Chin eYu, Kazuhiro eChida, Shin-Ichiro eTakahashi   +12 more
doaj   +1 more source

Insulin and insulin receptors in rodent brain [PDF]

Diabetologia, 1981
While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding.
Havrankova, J, Brownstein, M, Roth, J
openaire   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk [PDF]

, 2010
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins.
Linda Partridge, Partridge, L., Withers, D., Stocker, H, Withers, D.J., Foley, A., Foley, Andrea, Hafen, Ernst, Cathy Slack, Thornton, Janet M., Werz, C, Wieser, D, Stocker, Hugo, Thornton, J., Slack, C, Wieser, D., Werz, C., Hafen, E, Withers, Dominic J., Hafen, E., Lu, Bingwei, Dominic J Withers, Nazif Alic, Janet M Thornton, Werz, Christian, Alic, N, Stocker, H., Withers, DJ, Ernst Hafen, Partridge, Linda, Slack, Cathy, Hugo Stocker, Andrea Foley, Wieser, Daniela, Foley, A, Alic, Nazif, Partridge, L, Christian Werz, Thornton, JM, Alic, N., Daniela Wieser, Slack, C., Lu, B., Thornton, J. M.   +43 more
core   +1 more source

Insulin receptor and cancer

Endocrine-Related Cancer, 2011
The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in cancer progression.
Belfiore, Antonino, Malaguarnera, Roberta   +1 more
openaire   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Insulin Analogues for Insulin Receptor Studies and Medical Applications [PDF]

, 2012
The structure of insulin molecule was determined by Dorothy Hodgkin in 1969. Subsequently, it has been established that insulin must rearrange upon binding to its receptor (Insulin Receptor – IR).
Watson, Christopher John
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ROLE OF MUTATION OF INSULIN RECEPTOR GENES IN THE DEVELOPMENT OF THE PHENOMENON OF INSULIN RESISTANCE

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity
Nikonova L. V., Tishkovskiy S. V., Butrim O. S.   +2 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source