Results 41 to 50 of about 5,539,174 (299)

Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus [PDF]

, 2010
Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor. We present a 59-year-old Japanese man with type B insulin resistance complicated with systemic lupus erythematosus (SLE). A high titer of anti-insulin
Kawashiri, Shin-ya, Eguchi, Katsumi, Tamai, Mami, Nakamura, Hideki, Ida, Hiroaki, Kawakami, Atsushi, Fujikawa, Keita, Origuchi, Tomoki, Aramaki, Toshiyuki, Iwamoto, Naoki   +9 more
core   +1 more source

Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIon transport in the renal proximal tubule (RPT), which is increased in essential hypertension, is regulated by numerous hormones and humoral factors, including insulin and dopamine. Activation of dopamine receptor inhibits sodium reabsorption,
Ye Zhang, Hongmei Ren, Xi Lu, Duofen He, Yu Han, Hongyong Wang, Chunyu Zeng, Weibin Shi   +7 more
doaj   +1 more source

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*

Journal of Biological Chemistry, 2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which
Chun-Li Yu, Yan Chen, G. Cline, Dong-Yan Zhang, Hai-Hong Zong, Yanlin Wang, R. Bergeron, Jason K. Kim, S. W. Cushman, G. Cooney, Bronwyn A. Atcheson, M. White, E. Kraegen, G. Shulman   +13 more
semanticscholar   +1 more source

Palosuran: clinical pharmacology of a urotensin-II receptor antagonist in type 2 diabetes mellitus [PDF]

, 2015
Type 2 Diabetes Mellitus (Type 2 DM) is a growing global public health threat, leading to a significant cost burden to society. Type 2 DM increases the risk of hypertension and associated macro- and microcardiovascular diseases, affecting the eyes ...
Sidharta, Patricia N.
core   +1 more source

Insulin analogs and cancer

Frontiers in Endocrinology, 2012
Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca, Rosario eLe Moli, Riccardo eVigneri   +2 more
doaj   +1 more source

Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells

Diabetes & Vascular Disease Research, 2022
Insulin receptors are internalized by endothelial cells to facilitate their physiological processes; however, the impact of hyperinsulinemia in brain endothelial cells is not known. Thus, the aim of this study was to elucidate the impact hyperinsulinemia
Luke S Watson, Brynna Wilken-Resman, Alexus Williams, Stephanie DiLucia, Guadalupe Sanchez, Taylor L McLeod, Catrina Sims-Robinson   +6 more
doaj   +1 more source

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Persaud, Shanta J.; id_orcid, Jones, Peter M.; id_orcid, Kitsou-Mylona, Isidora, Squires, Paul E., Jones, Peter M., Burns, Christopher J., Persaud, Shanta J.   +6 more
core   +1 more source

GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art

Molecular Metabolism, 2020
Background GLP-1 receptor agonists (GLP-1 RAs) with exenatide b.i.d. first approved to treat type 2 diabetes in 2005 have been further developed to yield effective compounds/preparations that have overcome the original problem of rapid elimination (short
M. Nauck, D. Quast, J. Wefers, J. Meier
semanticscholar   +1 more source

The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins

Frontiers in Endocrinology, 2015
Insulin-like peptides, such as insulin and insulin-like growth factors (IGFs), induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism and decreased catabolism in many cell types and in vivo.
Fumihiko eHakuno, Toshiaki eFukushima, Toshiaki eFukushima, Yosuke eYoneyama, Hiroyasu eKamei, Atsufumi eOzoe, Hidehito eYoshihara, Daisuke eYamanaka, Takashi eShibano, Meri eSone-Yonezawa, Bu-Chin eYu, Kazuhiro eChida, Shin-Ichiro eTakahashi   +12 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Kiess, W., Kolb, H. J., Funk, B., Kessler, U., Hansmann, A.   +5 more
core   +1 more source