Results 31 to 40 of about 5,539,174 (299)
Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in ...
Hongzhou Liu +5 more
doaj +1 more source
Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes
Neuron, 2017 SUMMARY Diabetes and impaired brain insulin signaling are linked to the pathogenesis of Alzheimer’s disease (AD). The association between diabetes and AD-associated amyloid pathology is stronger among carriers of the apolipoprotein E (APOE) ε4 gene ...
Na Zhao +8 more
semanticscholar +1 more source
Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond
Frontiers in Endocrinology, 2022 The mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. Significant advances have been gained from recent structural studies in understanding how insulin binds to its receptor.
Shee Chee Ong +7 more
doaj +1 more source
Insulin transport across the blood–brain barrier can occur independently of the insulin receptor
Journal of Physiology, 2018 Insulin enters the brain from the blood via a saturable transport system. It is unclear how insulin is transported across the blood–brain barrier (BBB).
E. Rhea, C. Rask-Madsen, W. Banks
semanticscholar +1 more source
Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Nature Communications, 2022 DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of ...
Junhong Kim +8 more
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2023 Severe insulin resistance can be caused by rare genetic defects in the insulin receptor known as insulin receptoropathies. These genetic defects cause a wide spectrum of clinical manifestations ranging from mild syndromes to lethal disorders. Among those
Dalia Cuenca +11 more
doaj +1 more source
Frontiers in Endocrinology, 2011 Ever since the discovery of insulin and its role in the regulation of glucose uptake and utilization, there has been great interest in insulin, its structure and the way in which it interacts with its receptor and effects signal transduction. As the 90th
Michael eLawrence, Michael eLawrence
doaj +1 more source
Insulin receptor has tyrosine kinase activity toward Shc in rat liver
Brazilian Journal of Medical and Biological Research, 1998 Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa +3 more
doaj +1 more source
The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney
Biomedicines, 2021 The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([125I]TyrA14)-insulin by ...
Rick I. Meijer, Eugene J. Barrett
doaj +1 more source
Cell, 2010 SUMMARY Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here we show that the G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA receptor/sensor.
D. Oh +9 more
semanticscholar +1 more source