Results 31 to 40 of about 502,774 (317)

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Weber, Matthias M., Fottner, Christian, Simmler, Pia, Engelhardt, Dieter   +3 more
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Landmarks in insulin research

Frontiers in Endocrinology, 2011
Ever since the discovery of insulin and its role in the regulation of glucose uptake and utilization, there has been great interest in insulin, its structure and the way in which it interacts with its receptor and effects signal transduction. As the 90th
Michael eLawrence, Michael eLawrence
doaj   +1 more source

The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney

Biomedicines, 2021
The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([125I]TyrA14)-insulin by ...
Rick I. Meijer, Eugene J. Barrett
doaj   +1 more source

Insulin receptor has tyrosine kinase activity toward Shc in rat liver

Brazilian Journal of Medical and Biological Research, 1998
Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa, C.R.O. Carvalho, L.A. Velloso, M.J.A. Saad   +3 more
doaj   +1 more source

Molecular mechanisms of insulin resistance in chronic liver disease [PDF]

, 2008
The work presented here analyses the role of PP2A in the dysregulation of glucose metabolism in the setting of chronic hepatitis C. We propose a new model for virus induced insulin resistance development through the overexpression of PP2A in the liver ...
Bernsmeier, Christine
core   +1 more source

Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIon transport in the renal proximal tubule (RPT), which is increased in essential hypertension, is regulated by numerous hormones and humoral factors, including insulin and dopamine. Activation of dopamine receptor inhibits sodium reabsorption,
Ye Zhang, Hongmei Ren, Xi Lu, Duofen He, Yu Han, Hongyong Wang, Chunyu Zeng, Weibin Shi   +7 more
doaj   +1 more source

Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus [PDF]

, 2010
Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor. We present a 59-year-old Japanese man with type B insulin resistance complicated with systemic lupus erythematosus (SLE). A high titer of anti-insulin
Kawashiri, Shin-ya, Eguchi, Katsumi, Tamai, Mami, Nakamura, Hideki, Ida, Hiroaki, Kawakami, Atsushi, Fujikawa, Keita, Origuchi, Tomoki, Aramaki, Toshiyuki, Iwamoto, Naoki   +9 more
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Insulin analogs and cancer

Frontiers in Endocrinology, 2012
Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca, Rosario eLe Moli, Riccardo eVigneri   +2 more
doaj   +1 more source

Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells

Diabetes & Vascular Disease Research, 2022
Insulin receptors are internalized by endothelial cells to facilitate their physiological processes; however, the impact of hyperinsulinemia in brain endothelial cells is not known. Thus, the aim of this study was to elucidate the impact hyperinsulinemia
Luke S Watson, Brynna Wilken-Resman, Alexus Williams, Stephanie DiLucia, Guadalupe Sanchez, Taylor L McLeod, Catrina Sims-Robinson   +6 more
doaj   +1 more source

Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? [PDF]

, 2010
<p><b>Background:</b> South Asians are more insulin resistant than Europeans, which cannot be fully explained by differences in adiposity. We investigated whether differences in oxidative capacity and capacity for fatty acid utilisation
Nita G Forouhi, Jason M R Gill, Hall, L.M.L., Hariharan, Narayanan, Salt, I.P., Hall, Lesley M L, Wilson, John, Niall G. MacFarlane, Niall G MacFarlane, Sattar, N., Milne, Gillian R, Gillian R Milne, MacFarlane, N.G., Gill, Jason M R, Gill Jason M. R., Lesley M. L. Hall, Moran Colin N., John Wilson, Sattar Naveed, Jason M. R. Gill, Colin N Moran, Gillian R. Milne, MacFarlane Niall G., Lesley M L Hall, Forouhi, N.G., MacFarlane, Niall G, Hariharan, N., Ian P Salt, Colin N. Moran, Hariharan Narayanan, Milne, G.R., Sattar, Naveed, Gill, J.M.R., Moran, C.N., Milne Gillian R., Nita G. Forouhi, Forouhi Nita G., Salt Ian P., Naveed Sattar, Narayanan Hariharan, Moran, Colin Neil, Hall Lesley M. L., Forouhi, Nita G, Salt, Ian P, Ian P. Salt, Wilson John   +45 more
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