Results 21 to 30 of about 5,539,174 (299)

Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis

Nature, 2018
The insulin receptor is a dimeric protein that has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels.
G. Scapin, V. Dandey, Zhe-Ning Zhang, W. Prosise, A. Hruza, Theresa M. Kelly, T. Mayhood, C. Strickland, C. Potter, B. Carragher   +9 more
semanticscholar   +1 more source

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection.

Cell Metabolism, 2018
T cells represent a critical effector of cell-mediated immunity. Activated T cells engage in metabolic reprogramming during effector differentiation to accommodate dynamic changes in energy demands. Here, we show that the hormone, insulin, and downstream
Sue Tsai, X. Clemente-Casares, Angela C. Zhou, Helena Lei, Jennifer Ahn, Yi-Tao Chan, Okmi Choi, Helen Luck, M. Woo, S. Dunn, E. Engleman, T. Watts, S. Winer, D. Winer   +13 more
semanticscholar   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

Journal of Pathology, 2018
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics.
André F. Batista, Letícia Forny-Germano, J. Clarke, N. L. E. Silva, Jordano Brito‐Moreira, S. Boehnke, A. Winterborn, B. Coe, Ann Lablans, Juliana F. S. Vital, S. A. Marques, Anita M. Martinez, Matthias Gralle, C. Hölscher, W. Klein, J. Houzel, S. Ferreira, D. Munoz, F. D. De Felice   +18 more
semanticscholar   +1 more source

Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons

BMC Neuroscience, 2007
Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G, Persiyantseva Nadezhda A, Senilova Yana E, Storozhevykh Tatiana P, Pomytkin Igor A   +4 more
doaj   +1 more source

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

Endocrine reviews, 2017
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms, IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and appear to be determined by their different binding affinities for insulin-
A. Belfiore, R. Malaguarnera, V. Vella, M. Lawrence, L. Sciacca, F. Frasca, A. Morrione, R. Vigneri   +7 more
semanticscholar   +1 more source

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
core   +1 more source

Insulin-mediated modulation of NMDA receptor currents in Xenopus oocytes.

, 2005
Insulin-mediated modulation of NMDA receptor currents in Xenopus ...
Michelle L. Jones (7986683)
core   +4 more sources

The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on [PDF]

, 2008
In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma
Hills, Claire E., Hodgkin, M. N., Squires, Paul E.   +2 more
core   +1 more source

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Guse, Andreas H., Kessler, Ulrike, Funk, Barbara, Gercken, Günther, A. H. Guse, Kiess, Wieland   +6 more
core   +2 more sources