Results 21 to 30 of about 770,344 (300)

Insulin antibodies prevent insulin-receptor interactions [PDF]

Diabetologia, 1980
The study was carried out to investigate whether insulin bound to antibody is able to bind the insulin receptor of target tissues. Three specific rabbit anti-insulin sera as well as sera from eight diabetic patients with insulin antibodies were incubated, free of insulin, with labelled insulin for 48 h at 4 degrees C; following incubation labelled ...
R, de Pirro, A, Fusco, L, Spallone, R, Magnatta, R, Lauro   +4 more
openaire   +2 more sources

Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. [PDF]

PLoS ONE, 2013
We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet.
David J Pedersen, Barbara Diakanastasis, Jacqueline Stöckli, Carsten Schmitz-Peiffer   +3 more
doaj   +1 more source

Engineering of insulin receptor isoform-selective insulin analogues. [PDF]

PLoS ONE, 2011
BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf, Carsten E Stidsen, Mathias Norrman, Erica Nishimura, Anders R Sørensen, Thomas Kjeldsen   +5 more
doaj   +1 more source

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

Tolerability and Effectiveness of Switching to Dulaglutide in Patients With Type 2 Diabetes Inadequately Controlled With Insulin Therapy

Frontiers in Endocrinology, 2022
AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim, Ji Hye Huh, Minyoung Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee   +5 more
doaj   +1 more source

When intensive insulin therapy (MDi) fails in patients with type 2 diabetes: Switching to GLP-1 receptor agonist versus insulin pump [PDF]

, 2016
Treatment with insulin, alone or with oral or injectable hypoglycemic agents, is becoming increasingly common in patients with type 2 diabetes. However, approximately 40% of patients fail to reach their glycemic targets with the initially prescribed ...
Castaneda, Javier, Cohen, Ohad, FILETTI, SEBASTIANO, Glandt, Mariela, MARANGHI, MARIANNA   +4 more
core   +2 more sources

The insulin receptor [PDF]

The Journal of Pediatrics, 1981
Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
openaire   +3 more sources

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro

Frontiers in Endocrinology, 2014
Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein, Patrick F. Dillon, Abigail ePodufaly   +2 more
doaj   +1 more source

Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand

Scientific Reports, 2022
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison, Laura Wood, Karen J. Edler, James Doutch, Gareth J. Price, Francoise Koumanov, Paul Whitley   +6 more
doaj   +1 more source

Inhibition of Y1 receptor signaling improves islet transplant outcome [PDF]

, 2017
Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation.
A Ali-Rachedi, A Thonpho, AD Nguyen, AG Nieuwenhuizen, AM Shapiro, AM Shapiro, American Diabetes, A., AR Saltiel, C Ammala, C Postic, C Ricordi, C Ricordi, CR Gustavsen, D Boey, D Boey, D Ize-Ludlow, DL Eizirik, DM Sousa, E Karra, G Bertrand, H Matsuda, H Yajima, HA Wieland, J Cantley, JM Sosenko, JY Kim, K Loh, K Yang, L Zhang, L Zhang, LA Selbie, M Jackerott, N Butta, O Idevall-Hagren, RA Stokes, RL Batterham, RP Robertson, S Kassis, S Seino, S Walters, T Yada, TL Belle van, TT Ngo, W Shao, Y Kashima, YC Shi, YC Shi   +46 more
core   +5 more sources