Results 11 to 20 of about 5,539,174 (299)
Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro [PDF]
Frontiers in Endocrinology, 2014 Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein +2 more
doaj +2 more sources
Insulin Analogues for Insulin Receptor Studies and Medical Applications [PDF]
, 2012 The structure of insulin molecule was determined by Dorothy Hodgkin in 1969. Subsequently, it has been established that insulin must rearrange upon binding to its receptor (Insulin Receptor – IR).
Watson, Christopher John
core +6 more sources
A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose-driven glioblastoma. [PDF]
Mol OncolThe novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Rurka P +9 more
europepmc +2 more sources
Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
doaj +1 more source
Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. [PDF]
PLoS ONE, 2013 We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet.
David J Pedersen +3 more
doaj +1 more source
Frontiers in Endocrinology, 2022 AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim +5 more
doaj +1 more source
Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
doaj +1 more source
eLife, 2019 Insulin signaling controls metabolic homeostasis. Here, we report the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state. This structure unexpectedly reveals that maximally four insulins can bind the ‘T’-shaped
E. Uchikawa +4 more
semanticscholar +1 more source
Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
bioRxiv, 2019 Glucose homeostasis and growth essentially depend on the peptide hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor ...
T. Gutmann +6 more
semanticscholar +1 more source
Scientific Reports, 2022 Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison +6 more
doaj +1 more source