Results 61 to 70 of about 2,068,287 (293)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of acute rosiglitazone on insulin pharmacokinetics at the blood‐brain barrier

Endocrinology, Diabetes & Metabolism, 2020
Introduction CNS insulin levels are decreased and insulin receptor signalling is dampened in Alzheimer's disease (AD). Increasing CNS insulin levels through a variety of methods has been shown to improve memory.
Demi C. Galindo, William A. Banks, Elizabeth M. Rhea   +2 more
doaj   +1 more source

Insulin signaling and its application

Frontiers in Endocrinology, 2023
The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance.
Thi Kim Chung Le, Xuan Dat Dao, Dang Vung Nguyen, Duc Huy Luu, Thi Minh Hanh Bui, Thi Huong Le, Huu Thang Nguyen, Tran Ngoan Le, Toshio Hosaka, Thi Thu Thao Nguyen   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The signalling conformation of the insulin receptor ectodomain

Nature Communications, 2018
The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete.
Felix Weis, John G. Menting, Mai B. Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W. Müller, Matthias K. Dreyer, Michael C. Lawrence   +10 more
doaj   +1 more source

Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin [PDF]

, 2001
Cdc42Hs is involved in cytoskeletal reorganization and is required for neurite outgrowth in N1E-115 cells. To investigate the molecular mechanism by which Cdc42Hs regulates these processes, a search for novel Cdc42Hs protein partners was undertaken by ...
Sheila Govind, Louis Lim, Ahmed, S., Clinton Monfries, Kozma, R., Robert Kozma, Lim, L., Govind, S., Monfries, C., Sohail Ahmed   +9 more
core   +1 more source

New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics

Journal of Pharmacological Sciences, 2005
Long after the pioneering studies documenting the existence of insulin (year 1967) and insulin receptor (year 1978) in brain, the last decade has witnessed extraordinary progress in the understanding of brain region-specific multiple roles of insulin ...
Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayashi   +3 more
doaj   +1 more source

Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism [PDF]

, 2004
The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function.
Pljesa, Steva, Komadina, Ljiljana, Milic, Natasa, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Perunicic-Pekovic, Gordana   +5 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source