Results 121 to 130 of about 3,525,166 (333)
Arthritis Care &Research, EarlyView.Objective The objective of this study was to evaluate and compare the risk of hepatotoxicity associated with the use of febuxostat and benzbromarone in patients with gout. Methods New users of febuxostat or benzbromarone with monitoring of liver function at least three times in a year after initiation of the study drugs were identified from an ...
Wenyan Sun +8 more
wiley +1 more source
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling. [PDF]
J Biol Chem, 2022 Gayen M +4 more
europepmc +1 more source
Advanced Biology, EarlyView.The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua +5 more
wiley +1 more source
An Artificial Insulin Receptor that Self-assembles and Works on a Gold Surface
ElectrochemistryA novel artificial insulin receptor was developed, that can self-assemble on a gold surface and alter its structure in response to insulin recognition via partial domains of the intrinsic insulin receptor.
Yusuke MURAI +9 more
doaj +1 more source
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
Nature Communications, 2018 A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent ...
Paul J. Meakin +11 more
doaj +1 more source
The regulation of insulin receptor/insulin-like growth factor 1 receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1. [PDF]
J Hematol Oncol, 2022 Nguyen TNQ +10 more
europepmc +1 more source
Key Trends and Insights in Smart Polymeric Skin Wearable Patches
Advanced Engineering Materials, EarlyView.Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez +2 more
wiley +1 more source
Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility
Scientific ReportsThe production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production ...
Esra Ayan
doaj +1 more source
Acta Obstetricia et Gynecologica Scandinavica, 1997 Background. The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue, and to compare ...
Shiuh Y. Chang, Yat‐Sen Ho
doaj +1 more source
EBioMedicine, 2016 Low-density lipoprotein receptor-related protein-1 (LRP1) is a multifunctional uptake receptor for chylomicron remnants in the liver. In vascular smooth muscle cells LRP1 controls reverse cholesterol transport through platelet-derived growth factor ...
Yinyuan Ding +4 more
doaj +1 more source