Results 291 to 300 of about 681,804 (310)

Insulin Receptor Autoimmunity and Insulin Resistance

Journal of Pediatric Endocrinology and Metabolism, 2008
The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping Zhou, Maria G. Vogiatzi, Noel K. Maclaren, Svetlana Ten, Svetlana Ten, Sunil Sinha, Sunil Sinha, Neesha Ramchandani, Neesha Ramchandani   +8 more
openaire   +2 more sources

Mutations in the insulin receptor gene

Endocrine Reviews, 1992
I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI, CAMA, A, ACCILI, D, BARBETTI, F, QUON, MJ, SIERRA, MD, SUZUKI, Y, KOLLER, E, LEVYTOLEDANO, R, WERTHEIMER, E, MONCADA, VY, KADOWAKI, H, KADOWAKI, T   +12 more
openaire   +6 more sources

The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors

Endocrinology, 1977
Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of four insulin analogues ...
Barry H. Ginsberg, Jesse Roth, Ronald Kahn   +2 more
openaire   +3 more sources

Insulin receptors and the site of action of insulin

Life Sciences, 1978
Abstract There is considerable evidence that insulin receptors located on the plasma membrane of target cells directly mediate the short- term effects of insulin on plasma membrane functions such as glucose transport. These receptors are composed of four subunits, contain two or more binding sites, and show features of negative cooperativity. Insulin
openaire   +3 more sources

Evolution of Insulin and Insulin Receptors

1987
Insulin traditionally has been considered to be a unique product of the vertebrate pancreas. More recent studies, however, have suggested that there may be extrapancreatic sources of insulin and that insulin may act on tissues other than its classic target tissues.
William L. Lowe, Derek LeRoith, Charles T. Roberts   +2 more
openaire   +2 more sources

The insulin receptor

1989
Many hormones and other extracellular stimuli exert their effects by binding to specific receptors on the plasma membrane of cells. The receptors recognize and bind the agonists with high affinity, and are therefore responsible for initiating the cascade of reactions leading to intracellular events. The hormone-receptor complex transmits this signal in
openaire   +2 more sources

Insulin Receptors

Annual Review of Medicine, 1973
B, Desbuquois, P, Cuatrecasas
openaire   +2 more sources

Insulin Receptors

Annual Review of Pharmacology and Toxicology, 1983
S, Jacobs, P, Cuatrecasas
openaire   +2 more sources

Insulin Receptor

2021
André Kleinridders, Hans-Georg Joost
openaire   +1 more source

Probing the insulin receptor [PDF]

Nature, 1979
openaire   +2 more sources