Results 291 to 300 of about 3,525,166 (333)
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Biochimie, 1985
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
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The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
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Autoantibodies to insulin receptors
Molecular and Cellular Endocrinology, 1981In summary, these studies using antibodies to the insulin receptor have provided some new insights into the structure of the insulin receptor and the action of insulin itself. They suggest that most of insulin's actions are mediated through a common pathway and these can be initiated by interaction of ligands other than insulin with the insulin ...
C. Ronald Kahn, Emmanuel Van Obberghen
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Science, 1997
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage.
Koutarou D. Kimura +3 more
semanticscholar +1 more source
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage.
Koutarou D. Kimura +3 more
semanticscholar +1 more source
1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
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Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
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The Immunology of the Insulin Receptor
Immunological Communications, 1976We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett +3 more
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Insulin Receptor and Insulin Action [PDF]
, 1990 Insulin generates a complex assay of biological responses in a variety of cell systems. The first step in insulin action is binding of the hormone to its specific cell surface receptor. This receptor is an oligomer consisting of two α-subunits with Mr 130 kDa, and twos-subunits with Mr 95 kDa; the different subunits are linked together by disulfide ...
E Van Obberghen, Robert Ballotti
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Insulin Receptor Antibodies and Insulin Resistance
Southern Medical Journal, 1999The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
Spencer J, Magsino Ch
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Insulin resistance: Review of the underlying molecular mechanisms
Journal of Cellular Physiology, 2018Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi +3 more
semanticscholar +1 more source
1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina +2 more
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The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina +2 more
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Insulin receptors and insulin signalling
1995International ...
Taouis, Mohammed, Simon, J.
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