β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. [PDF]
PLoS ONE, 2013 There is considerable evidence from our lab and others for a functional link between β-adrenergic receptor and insulin receptor signaling pathways in retina.
Youde Jiang +5 more
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Frontiers in Endocrinology, 2013 Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe +7 more
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Cellular Profile of Subfornical Organ Insulin Receptors in Mice
BiomoleculesBrain insulin receptor signaling is strongly implicated in cardiovascular and metabolic physiological regulation. In particular, we recently demonstrated that insulin receptors within the subfornical organ (SFO) play a tonic role in cardiovascular and ...
Han-Rae Kim +2 more
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Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
Frontiers in Endocrinology, 2017 A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production, which is the main contributing factor to diabetic ...
Jiří Jiráček, Lenka Žáková
doaj +1 more source
A model for insulin binding to the insulin receptor [PDF]
European Journal of Biochemistry, 1994 The affinities of a number of insulin analogues for the human insulin receptor, a truncated soluble form of the insulin receptor, and the human insulin‐like growth factor 1 receptor were determined. Insulin analogues with substitutions in the A13 or B17 positions were shown to have anomalous binding properties. This suggests that these positions, which
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An Artificial Insulin Receptor that Self-assembles and Works on a Gold Surface
ElectrochemistryA novel artificial insulin receptor was developed, that can self-assemble on a gold surface and alter its structure in response to insulin recognition via partial domains of the intrinsic insulin receptor.
Yusuke MURAI +9 more
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The Insulin/IGF system in colorectal cancer development and resistance to therapy
Frontiers in Oncology, 2015 The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri +6 more
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Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility
Scientific ReportsThe production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production ...
Esra Ayan
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver
Nature Communications, 2018 A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent ...
Paul J. Meakin +11 more
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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling. [PDF]
J Biol Chem, 2022 Gayen M +4 more
europepmc +1 more source