Results 51 to 60 of about 3,525,166 (333)

Insulin receptor has tyrosine kinase activity toward Shc in rat liver

Brazilian Journal of Medical and Biological Research, 1998
Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa, C.R.O. Carvalho, L.A. Velloso, M.J.A. Saad   +3 more
doaj   +1 more source

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.

Diabetes, 2003
Type 2 diabetes is a complex disease in which genetic and environmental factors interact to produce alterations in insulin action and insulin secretion, leading to hyperglycemia.
R. Kulkarni, K. Almind, H. Goren, J. Winnay, K. Ueki, T. Okada, C. Kahn   +6 more
semanticscholar   +1 more source

An insulin receptor mutant (Asp707 → Ala), involved in leprechaunism, is processed and transported to the cell surface but unable to bind insulin [PDF]

, 1996
We have identified a homozygous mutation near the carboxyl terminus of the insulin receptor (IR) α subunit from a leprechaun patient, changing Asp707 into Ala. Fibroblasts from this patient had no high affinity insulin binding sites.
Apak, M.Y. (Memnune), Hart, L.M. (Leen) 't, Kayserilli, H. (Hülya), Kleijer, W.J. (Wim), Lindhout, D. (Dick), Maassen, J.A. (Johannes), Vorm, E.R. (Eric) van der, Zon, G.C.M. (Gerard) van der   +7 more
core   +1 more source

Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIon transport in the renal proximal tubule (RPT), which is increased in essential hypertension, is regulated by numerous hormones and humoral factors, including insulin and dopamine. Activation of dopamine receptor inhibits sodium reabsorption,
Ye Zhang, Hongmei Ren, Xi Lu, Duofen He, Yu Han, Hongyong Wang, Chunyu Zeng, Weibin Shi   +7 more
doaj   +1 more source

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

Journal of Clinical Investigation, 1993
Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI 3-kinase), thus activating ...
Mário, J. A. Saad, Franco, Folli, Jeffrey A. Kahn, C. R. Kahn   +5 more
semanticscholar   +1 more source

Brefeldin A inhibits insulin-dependent receptor redistribution in HIRcB cells [PDF]

, 1995
Brefeldin A (BFA) is a potent inhibitor of intracellular vesicle traffic. We have investigated the effects of BFA on the traffic of the insulin receptor in HIRcB cells, a cell line derived from Rat-1 fibroblasts that over-expresses a normal human insulin
Bergeron, Carpentier, Chou, Clark, Damke, Dent, Doherty, Donaldson, Donaldson, Donaldson, Ebina, Fujiwara, Hammel, Helms, Hunziker, Kahn, Kasuga, Klausner, Knutson, Knutson, Lachaal, Levy, McClain, McClain, McClain, Randazzo, Robinson, Rolband, Rosen, Smith, Smith, Smith, Stentz, Wan, Wong, Wood   +35 more
core   +1 more source

Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. [PDF]

, 2015
Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to
Aznar, Nicolas, Ciaraldi, Theodore P, Ghosh, Pradipta, Henry, Robert R, Kalogriopoulos, Nicholas, Lopez-Sanchez, Inmaculada, Ma, Gary S, Midde, Krishna, Pedram, Shabnam   +8 more
core   +2 more sources

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

Journal of Pathology, 2018
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics.
A. F. Batista, Letícia Forny‐Germano, J. Clarke, Natalia M. Lyra e Silva, Jordano Brito‐Moreira, S. Boehnke, A. Winterborn, B. Coe, Ann Lablans, Juliana F. S. Vital, S. A. Marques, Anita M. Martinez, Matthias Gralle, C. Holscher, W. Klein, J. Houzel, S. Ferreira, D. Munoz, F. D. De Felice   +18 more
semanticscholar   +1 more source

ROLE OF MUTATION OF INSULIN RECEPTOR GENES IN THE DEVELOPMENT OF THE PHENOMENON OF INSULIN RESISTANCE

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity
Nikonova L. V., Tishkovskiy S. V., Butrim O. S.   +2 more
doaj   +1 more source

The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes [PDF]

, 1991
We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes.
Drenkhan, M., Klein, H. H., Matthaei, S., Ries, W., Scriba, Peter Christian   +4 more
core