Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. [PDF]
PLoS ONE, 2017 Obesity is often associated with dyslipidemia and hepatosteatosis. A number of animal models of non-alcoholic fatty liver disease (NAFLD) are established but they significantly differ in the molecular and biochemical changes depending on the genetic ...
Vera Lede +11 more
doaj +5 more sources
Jurnal Medik Veteriner, 2023 Etawah crossbreed and Senduro goats as superior local goats and biological genetic resources that must be preserved in Indonesia. Melanocortin receptor type 4 (MC4R) is the primary gene that regulates food intake and energy balance which can be used as a
Ristaqul Husna Belgania +4 more
doaj +3 more sources
Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor. [PDF]
PLoS ONE, 2016 Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on vascular atherogenesis is not known.
Vera Lede +9 more
doaj +6 more sources
Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. [PDF]
PLoS ONE, 2012 Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity.
Theodore P Braun +8 more
doaj +6 more sources
Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Nesfatin-1 (NF-1), an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative inotropic effects.
Jiaoqian Ying +7 more
doaj +3 more sources
Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
Frontiers in Neuroscience, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson +3 more
doaj +4 more sources
Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. [PDF]
PLoS ONE, 2011 The hypothalamic melanocortin system--the melanocortin receptor of type 4 (MC4R) and its ligands: α-melanin-stimulating hormone (α-MSH, agonist, inducing hypophagia), and agouti-related protein (AgRP, antagonist, inducing hyperphagia)--is considered to ...
Bruno Pillot +10 more
doaj +2 more sources
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity
JCI Insight, 2021 MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The present study aimed at determining whether pharmacological chaperones (PCs)
Patricia René +3 more
doaj +2 more sources
Signal Transduction and Targeted TherapyObesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with ...
André Nguyen Dietzsch +23 more
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The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani +5 more
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