Results 141 to 150 of about 3,161 (162)

Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors

Biochemical Pharmacology, 2008
In order to interpret the effects of melatonin ligands in rats, we need to determine their activity at the receptor subtype level in the corresponding species. Thus, the rat melatonin rMT(1) receptor was cloned using DNA fragments for exon 1 and 2 amplified from rat genomic DNA followed by screening of a rat genomic library for the full length exon ...
Valérie, Audinot, Anne, Bonnaud, Line, Grandcolas, Marianne, Rodriguez, Nadine, Nagel, Jean-Pierre, Galizzi, Ales, Balik, Sophie, Messager, David G, Hazlerigg, Perry, Barrett, Philippe, Delagrange, Jean A, Boutin   +11 more
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Molecular Modeling of Human MT1 and MT2 Melatonin Receptors

2006
Malfunction of G-protein coupled receptors (GPCR) provokes large amount of diseases. Their adequate treatment requires rational design of new high affinity and high selectivity drugs targeting these receptors. Molecular modeling represents a powerful tool to solve the problem.
A. Chugunov, P. Chavatte, R. Efremov
openaire   +1 more source

Molecular pharmacology of the mouse melatonin receptors MT1 and MT2

European Journal of Pharmacology, 2012
The main melatonin receptors are two G-protein coupled receptors named MT(1) and MT(2). Having described the molecular pharmacology of the human versions of these receptors, we turned to two of the three species most useful in studying melatonin physiology: rat and sheep (a diurnal species used to understand the relationship between circadian rhythm ...
Devavry, Séverine, Legros, Celine, Brasseur, Chantal, Cohen, William, Guénin, Sophie-Pénélope, Delagrange, Philippe, Malpaux, Benoit, Ouvry, Christine, Cogé, Francis, Nosjean, Olivier, Boutin, Jany   +10 more
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Functional MT1 and MT2 melatonin receptors in mammals.

Endocrine, 2005
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 G protein-coupled receptors viewed as potential targets for drug discovery.
Margarita L, Dubocovich, Magdalena, Markowska   +1 more
openaire   +1 more source

Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection.

Journal of pineal research, 2011
Recent studies have demonstrated that the human placenta is a novel source of adult stem cells. We have provided laboratory evidence that transplantation of these human placenta-derived cells in vitro and in vivo stroke models promotes functional recovery.
Kaneko, Yuji, Hayashi, Takuro, Yu, Seongjin, Tajiri, Naoki, Bae, Eunkyung C, Solomita, Marianna A, Chheda, Sonia H, Weinbren, Nathan L, Parolini, Ornella, Borlongan, Cesar V.   +9 more
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Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors

Biochemical Pharmacology, 2004
The variations of the pharmacological properties of melatonin receptors between different mammalian species in transfected cell lines have been poorly investigated. In the present study, melatonin analogues have been used to characterize the pharmacology of the recombinant ovine melatonin receptor (oMT1) expressed in CHO cell lines and the native oMT1 ...
Mailliet, F., Audinot, V., Malpaux, Benoit, Bonnaud, Anthony, Delagrange, P., Migaud, Martine, Barrett, P., Viaud-Massuard, M.C., Lesieur, D., Lefoulon, F., Renard, P., Boutin, Jany   +11 more
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Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development

Zygote, 2010
SummaryIt is well known that melatonin provokes reproductive alterations in response to changes in hours of daylight in seasonally breeding mammals, exerting a regulatory role at different levels of the hypothalamic–pituitary–gonadal axis. Although it has also been demonstrated that melatonin may affect testicular activity in vertebrates, until now ...
IZZO G., ANIELLO F., FERRARA D., CAMPITIELLO M. R., SERINO, Ismene, MINUCCI, Sergio, D'ISTRIA M.   +6 more
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Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain

Current Medicinal Chemistry, 2018
Melatonin (MLT) has been implicated in several pathophysiological states, including pain. MLT mostly activates two G-protein coupled receptors, MT1 and MT2. In this review, we present the analgesic properties of MLT in preclinical and clinical studies, giving particular emphasis to the effects mediated by MT2 receptors and to recent investigations ...
Posa, Luca, De Gregorio, Danilo, Gobbi, Gabriella, COMAI, STEFANO   +3 more
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Selective MT2 melatonin receptor antagonist blocks melatonin-induced antinociception in rats

Neuroscience Letters, 2000
The present study was undertaken to assess the effects of intracerebroventricular (i.c.v.) luzindole (a selective MT(2) melatonin receptor antagonist) and prazosin (a selective MT(3) melatonin receptor antagonist) on melatonin-induced antinociception, so as to clarify which of melatonin receptor subtypes within the central nervous system (CNS) was ...
C X, Yu, C B, Zhu, S F, Xu, X D, Cao, G C, Wu   +4 more
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MT2 selective melatonin receptor antagonists: design and structure-activity relationships

2005
Second Joint Italian-Swiss Meeting on Medicinal Chemistry Poster SC-15 -
RIVARA S, MOR M, LORENZI S, LODOLA A, PLAZZI PV, SPADONI, GILBERTO, BEDINI, ANNALIDA, TARZIA, GIORGIO   +7 more
openaire   +2 more sources