Results 91 to 100 of about 58,465 (248)

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

Journal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi, Seri Kaeriyama, Akiko Muramatsu, Masumi Sato, Kunihiko Hirose, Nagako Shimizu, Hikaru Tanaka, Koki Shigenobu   +7 more
doaj   +1 more source

Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor (mAChR) M1 in the eyes of guinea pigs.
Yuan Tao, Xiao-Li Li, Li-Yuan Sun, Yu-Hua Wei, Xiao-Ting Yu, Hong Wang   +5 more
doaj   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]

, 1999
The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC, Brown, DA, Buckley, NJ, Delmas, P, Hadley, JK, London, B, Selyanko, AA, Wood, IC   +7 more
core   +1 more source

M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway

Neurobiology of Disease, 2004
Amyloid-β-peptide (Aβ) deposits are one of the hallmark features of Alzheimer's disease. Signal transduction alterations are implicate in the neuronal responses to Aβ, which include neurotransmitter systems and pathways involved in the maintenance of the
Ginny G. Farías, Juan A. Godoy, Félix Hernández, Jesús Avila, Abraham Fisher, Nibaldo C. Inestrosa   +5 more
doaj   +1 more source

Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Scientific Reports, 2022
Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor cells (OPCs).
Richard A. Seidman, Heba Khattab, Jessie J. Polanco, Jacqueline E. Broome, Fraser J. Sim   +4 more
doaj   +1 more source

Peptide Tags for Site‐Selective Nonenzymatic Covalent Modification of Proteins

Journal of Peptide Science, Volume 31, Issue 11, November 2025.
Highly selective chemical modification of peptides. This review describes peptide tags that direct covalent chemical modification of proteins. ABSTRACT Bioconjugation chemistry is an important tool for studying proteins, developing pharmaceutical agents, and for many other applications.
Delphine Nørgaard Møller, Christian Kofoed, Mikkel Boas Thygesen, Knud J. Jensen   +3 more
wiley   +1 more source

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]

, 2018
Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria, Caffarelli, Elisa, De Jaco, Antonella, Di Bari, Maria, Laneve, Pietro, Piovesana, Roberta, Talora, Claudio, Tata, Ada Maria, Trobiani, Laura   +8 more
core   +2 more sources

IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia

Pharmacological Research
Cobenfy, a co-formulation of xanomeline and trospium, is the first drug not acting on the dopaminergic system of the CNS approved for the treatment of schizophrenia by the FDA.
Brian Dean
doaj   +1 more source