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Editorial Expression of Concern for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Effects of Biperiden (Cholinergic Muscarinic m1/m4 Receptor Antagonist) on Craving Nicotine: A Proof-Of-Concept Clinical Study.

Eur Addict Res
Rosa Ciutti GL, Bezerra AG, Takahashi S, Jardim JR, Vicente R, Galduróz JCF, Palombo P.   +6 more
europepmc   +1 more source

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Two affinity states of M1 muscarine receptors

Cellular and Molecular Neurobiology, 1988
1. The binding of oxotremorine-M to M1 muscarine receptors was examined by measuring competition between the agonist and 3H-pirenzepine, using rabbit hippocampal membranes suspended in 20 mM Tris buffer containing 1 mM Mn2+. 2. Both ligands interacted with a single class of receptors.
L T, Potter, C A, Ferrendelli, H E, Hanchett   +2 more
openaire   +2 more sources

M1 and M3 muscarinic receptors

NeuroReport, 1992
P-fluoro-hexahydro-sila-difenidol hydrochloride (p-F-HHSiD) (15, 30 micrograms) and pirenzepine (7.5, 15, 30 micrograms), which are highly selective M3 and M1 muscarinic antagonists, respectively, were injected intracerebroventricularly into freely moving rats.
L. IMERI, S. BIANCHI, P. ANGELI, M. MANCIA   +3 more
openaire   +3 more sources