Results 171 to 180 of about 21,768 (201)

Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens

European Journal of Pharmacology, 1993
In the electrically field-stimulated rabbit vas deferens, muscarinic receptor agonists increase twitch-height by actions at postjunctional M2 receptors and decrease twitch-height by actions at prejunctional M1 receptors. In the present studies, in contrast to previous reports, muscarinic receptor agonists primarily decreased twitch-height, produced ...
H E, Shannon, B D, Sawyer, K G, Bemis, F P, Bymaster, I, Health, C H, Mitch, J S, Ward   +6 more
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Selectivity of oxomemazine for the M1 muscarinic receptors

Archives of Pharmacal Research, 1994
The binding characteristics of pirenzepine and oxomemazine to muscarinic receptor were studied to evaluate the selectivity of oxomemazine for the muscarinic receptor subtypes in rat cerebral microsomes. Equilibrium dissociation constant (KD) of (-)-[3H]quinuclidinyl benzilate([3H]QNB) determined from saturation isotherms was 64 pM.
S W, Lee, C W, Woo, J G, Kim
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Stable allosteric binding of m1-toxin to m1 muscarinic receptors.

Molecular Pharmacology, 1993
m1-Toxin was found to slow the dissociation of [3H]N-methyl-scopolamine (NMS) and [3H]pirenzepine from m1 muscarinic receptors expressed in the membranes of Chinese hamster ovary cells. When toxin-NMS-receptor complexes were formed in membranes and then dissolved in digitonin, or when these complexes were formed in solution, the toxin completely ...
S I, Max, J S, Liang, L T, Potter
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Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.

European Journal of Pharmacology, 2004
The muscarinic toxin MT7 is the most selective ligand for the muscarinic M(1) receptors. Previous studies have shown that the toxin interacts with the antagonist-receptor complex and slows the antagonist dissociation rate, possibly by binding to an allosteric site and impeding the access to and egress from the orthosteric binding pocket. In the present
OLIANAS, MARIA CONCETTA, ADEM A, KARLSSON E, ONALI, PIER LUIGI   +3 more
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Agonist induced phosphorylation of M1 muscarinic receptors

Life Sciences, 1995
73039
WAUGH, MG, NAHORSKI, S, TOBIN, AB
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Allosteric regulation of cloned m1–m5 muscarinic receptor subtypes

Biochemical Pharmacology, 1991
Allosteric regulation of [3H]N-methylscopolamine [( 3H]NMS) and [3H]quinuclidinyl benzilate [( 3H]QNB) dissociation from the m1-m5 muscarinic receptor subtypes was examined in transfected CHO-K1 cells. Half-times of dissociation of [3H]NMS from cell membranes (at 23 degrees) ranged from less than 5 min for the m2 subtype to more than 60 min for the m5 ...
J, Ellis, J, Huyler, M R, Brann
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Astrocytes have both M1 and M2 muscarinic receptor subtypes

Brain Research, 1986
In astrocytes, carbachol evoked the turnover of membrane inositol phospholipids prelabelled with [3H]inositol, as revealed by [3H]inositol phosphate accumulation in the presence of 5 mM lithium. This effect was blocked by atropine and by pirenzepine (IC50 2.2 nM and 56 nM, respectively).
S, Murphy, B, Pearce, C, Morrow
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M1 muscarinic receptor signaling in mouse hippocampus and cortex

Brain Research, 2002
The five subtypes (M1-M5) of muscarinic acetylcholine receptors signal through G(alpha)(q) or G(alpha)(i)/G(alpha)(o). M1, M3 and M5 receptors couple through G(alpha)(q) and function predominantly as postsynaptic receptors in the central nervous system.
Amy C, Porter, Frank P, Bymaster, Neil W, DeLapp, Masahisa, Yamada, Jürgen, Wess, Susan E, Hamilton, Neil M, Nathanson, Christian C, Felder   +7 more
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Autoantibodies against M1 muscarinic acetylcholine receptor in myasthenic disorders

European Journal of Neurology, 2007
The Lambert–Eaton myasthenic syndrome (LEMS), often associated with small‐cell lung carcinoma (SCLC), is a disorder of acetylcholine (ACh) release from motor nerve terminals. In most patients, it is caused by autoantibodies against the P/Q‐type voltage‐gated calcium channels (VGCC) that trigger ACh release. However, these antibodies are not detected in
M, Takamori, M, Motomura, T, Fukudome, H, Yoshikawa   +3 more
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Novel persistent activation of muscarinic M1 receptors by xanomeline

European Journal of Pharmacology, 1997
The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M1 receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (1 h) with 1 microM xanomeline, followed by extensive washing, resulted in a significantly elevated ...
A, Christopoulos, E E, El-Fakahany
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