Results 181 to 190 of about 21,768 (201)
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Muscarinic M1, M2 receptor binding. Relationship with functional efficacy
European Journal of Pharmacology, 1988A comparison has been made between [3H]pirenzepine binding to the M1 receptor population of rat cerebral cortex and [3H]N-methylscopolamine binding to M2 receptors in rat cardiac membranes. Several standard muscarinic antagonists including trihexyphenidyl HCl, benztropine, biperidin and 4-DAMP (4-diphenylacetoxy-N-methyl piperidine methiodide) showed ...
S B, Freedman, M S, Beer, E A, Harley
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Himbacine discriminates between putative muscarinic M1 receptor-mediated responses
Life Sciences, 1994This study describes the antagonistic properties of himbacine, in comparison with those of pirenzepine, at muscarinic receptors mediating the depolarization of rat superior cervical ganglion, the inhibition of electrically-induced twitch contractions of rabbit vas deferens and the contraction of dog saphenous vein, currently classified as putative ...
A, Sagrada +3 more
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Localization of M1 Muscarinic Receptors in Rat Brain Using Selective Muscarinic Toxin-1
Brain Research Bulletin, 1997Mambas, African snakes of the genus Dendroaspis, produce several types of toxins that are of pharmacological interest. The novel muscarinic toxin-1 (MT-1), from the green mamba Dendroaspis angusticeps, binds specifically to muscarinic M1 receptors in homogenates of rat cerebral cortex.
A, Adem +4 more
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Targeting the M1 muscarinic acetylcholine receptor in neurodegeneration
2023Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and to date, no disease-modifying treatments exist. The M1 muscarinic acetylcholine receptor (mAChR) is an established therapeutic target for the symptomatic treatment of AD, and drugs activating the M1 mAChR have been shown to improve cognitive decline and behavioural symptoms in ...
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Telenzepine enantiomers block muscarinic M1-receptors with opposite kinetics
European Journal of Pharmacology, 1990Stimulation of muscarinic M1-receptors in isolated rabbit vas deferens by McN-A-343 inhibited electrically induced twitch contractions susceptible to competitive blockade by (+)-, (+/-), (-)-telenzepine and pirenzepine (pA2 = 9.12, 8.86, 6.98 and 7.79, respectively).
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Naunyn-Schmiedeberg's Archives of Pharmacology, 1992
The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved.
S A, Darroch, L K, Choo, F, Mitchelson
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The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved.
S A, Darroch, L K, Choo, F, Mitchelson
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The distribution of muscarinic M1 receptors in the human hippocampus
Journal of Chemical Neuroanatomy, 2016The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions such as the hippocampus. To understand how the muscarinic M1 receptor achieves these functions in the hippocampus, it is critical to know the distribution of the receptor within this complex brain region.
Elizabeth Scarr +5 more
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Autoradiographic localization of peripheral M1 muscarinic receptors using [3H]pirenzepine
Brain Research, 1986A novel antimuscarinic agent, pirenzepine, has been proposed to distinguish at least two subtypes of muscarinic receptor. M1 receptors have been designated as those displaying a high affinity for pirenzepine. Both functional and binding studies have revealed a prevalence of M1 receptors in sympathetic ganglia while autonomic effector tissues have only ...
N J, Buckley, G, Burnstock
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Disinhibition in the rat septum mediated by M1 muscarinic receptors
Brain Research, 1988Acetylcholine (ACh) has been documented as an important central neurotransmitter. We have investigated the actions of ACh within the dorsolateral septal nucleus of the rat to examine its actions within this nucleus, specifically how it may interact to modulate the inhibitory action of gamma-aminobutyric acid (GABA), the known inhibitory transmitter in ...
H, Hasuo +2 more
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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
Nature Neuroscience, 2002Blockade of cholinergic neurotransmission by muscarinic receptor antagonists produces profound deficits in attention and memory. However, the antagonists used in previous studies bind to more than one of the five muscarinic receptor subtypes. Here we examined memory in mice with a null mutation of the gene coding the M1 receptor, the most densely ...
Stephan G, Anagnostaras +6 more
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