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Cholinergic modulation of upper airway control: maturational changes and mechanisms at cellular and synaptic levels. [PDF]
J NeurophysiolOsbourne A +5 more
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Selectivity of oxomemazine for the M1 muscarinic receptors
Archives of Pharmacal Research, 1994The binding characteristics of pirenzepine and oxomemazine to muscarinic receptor were studied to evaluate the selectivity of oxomemazine for the muscarinic receptor subtypes in rat cerebral microsomes. Equilibrium dissociation constant (KD) of (-)-[3H]quinuclidinyl benzilate([3H]QNB) determined from saturation isotherms was 64 pM.
Chang Woo Woo +2 more
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The distribution of muscarinic M1 receptors in the human hippocampus
Journal of Chemical Neuroanatomy, 2016The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions such as the hippocampus. To understand how the muscarinic M1 receptor achieves these functions in the hippocampus, it is critical to know the distribution of the receptor within this complex brain region.
Elizabeth Scarr +5 more
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Two affinity states of M1 muscarine receptors
Cellular and Molecular Neurobiology, 19881. The binding of oxotremorine-M to M1 muscarine receptors was examined by measuring competition between the agonist and 3H-pirenzepine, using rabbit hippocampal membranes suspended in 20 mM Tris buffer containing 1 mM Mn2+. 2. Both ligands interacted with a single class of receptors.
Cynthia A. Ferrendelli +2 more
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