Results 31 to 40 of about 24,428 (229)

Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]

, 2015
Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert, Hodges, Matthew, Miller, Justin Robert, Muere, Clarissa, Neumueller, Suzanne, Olesiak, Samantha, Pan, Lawrence   +6 more
core   +2 more sources

Intrinsic Gating Properties of a Cloned G Protein-activated Inward Rectifier K^+ Channel [PDF]

, 1995
The voltage-, time-, and K^+-dependent properties of a G protein-activated inwardly rectifying K^+ channel (GIRK1/KGA/Kir3.1) cloned from rat atrium were studied in Xenopus oocytes under two-electrode voltage clamp. During maintained G protein activation
Davidson, Norman, Doupnik, Craig A., Kofuji, Paulo, Lester, Henry A., Lim, Nancy F.   +4 more
core   +1 more source

Distribution of Muscarinic Acethylcholine Receptors and Related Signal [PDF]

Türk Biyokimya Dergisi, 2006
Muscarinic receptors are members of G protein coupled receptor family. Molecularcloning studies indicate five intronless genes that encode five muscarinic receptorglycoproteins.
Hülya Cabadak
doaj  

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +1 more source

Clinical Remission in Severe T2-High Asthma in Real Life After Anti-IgE, Anti-IL-5 and Anti-IL5R: A Potential Role for CRP as a Biomarker. [PDF]

Clin Transl Allergy
ABSTRACT Background Biotherapies have transformed the management of severe asthma (SA), shifting treatment goals from disease control toward achieving clinical remission. This study aimed to evaluate the effectiveness of biotherapies in inducing remission in severe asthma and to identify baseline patient characteristics that could predict remission ...
Vervier J, Sabbe M, Louis F, Moermans C, Guissard F, Sanchez C, Paulus V, Henket M, Philippe G, Beijnink CWH, Bridevaux PO, Schleich F, Louis R.   +12 more
europepmc   +2 more sources

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]

, 2018
Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria, Caffarelli, Elisa, De Jaco, Antonella, Di Bari, Maria, Laneve, Pietro, Piovesana, Roberta, Talora, Claudio, Tata, Ada Maria, Trobiani, Laura   +8 more
core   +2 more sources

Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments [PDF]

Journal of Biological Chemistry, 2004
Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single chain variable fragment with high affinity for its target epitope.
Jean-Christophe, Peter, Gerd, Wallukat, Jean, Tugler, Damien, Maurice, Jean-Christophe, Roegel, Jean-Paul, Briand, Johan, Hoebeke   +6 more
openaire   +2 more sources

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Journal of Pharmacological Sciences, 2008
The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious ...
Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano   +6 more
doaj   +1 more source

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]

, 2018
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J., Broad, Lisa M., Brooke, Simon M., Bundgaard, Christoffer, Christopoulos, Arthur, Crabtree, Michael D., Dwomoh, Louis, Felder, Christian C., Langmead, Christopher J., Mogg, Adrian J., Molloy, Colin, Sanger, Helen E., Sexton, Patrick M., Thompson, Karen J., Tobin, Andrew B.   +14 more
core   +1 more source

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor

eLife, 2016
The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown.
Rabindra V Shivnaraine, Brendan Kelly, Krishana S Sankar, Dar'ya S Redka, Yi Rang Han, Fei Huang, Gwendolynne Elmslie, Daniel Pinto, Yuchong Li, Jonathan V Rocheleau, Claudiu C Gradinaru, John Ellis, James W Wells   +12 more
doaj   +1 more source