Results 11 to 20 of about 12,342 (188)
Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor [PDF]
Membranes, 2015 The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
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Voltage affects the dissociation rate constant of the m2 muscarinic receptor. [PDF]
PLoS ONE, 2013 G-protein coupled receptors (GPCRs) comprise the largest protein family and mediate the vast majority of signal transduction processes in the body. Until recently GPCRs were not considered to be voltage dependent.
Yair Ben Chaim +3 more
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Activation and dynamic network of the M2 muscarinic receptor [PDF]
Proceedings of the National Academy of Sciences, 2013 G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear.
Yinglong, Miao +4 more
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Dualsteric modulators of the M2 muscarinic acetylcholine receptor [PDF]
Journal of Cheminformatics, 2014 G-protein coupled receptors (GPCRs) trigger multiple signal-switching mechanisms like binding of s-arrestin proteins, activation of kinases and G-protein activation [1]. The poor understanding of the conformational changes resulting in these activations is a major challenge for the design of specific GPCR modulating drugs.
Marcel Bermudez, Gerhard Wolber
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Sodium ions allosterically modulate the M2 muscarinic receptor [PDF]
Scientific Reports, 2020 AbstractG protein coupled receptors (GPCRs) play a key role in the vast majority of cellular signal transduction processes. Previous experimental evidence has shown that sodium ion (Na+) allosterically modulate several class A GPCRs and theoretical studies suggested that the same also holds true for muscarinic receptors. Here we examined, using Xenopus
Friedman, Sheli +2 more
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Effects of tetrahydroaminoacridine on M1 and M2 muscarine receptors
Neuroscience Letters, 1988 Tetrahydroaminoacridine (THA) has been reported to improve the memory of persons with Alzheimer's disease, but its mechanism of action is uncertain. We found that clinically effective concentrations, 0.03-0.3 microM, readily inhibit acetylcholinesterase and butyrylcholinesterase from rabbit hippocampal tissue in artificial cerebrospinal fluid (CSF) at ...
B D, Pearce, L T, Potter
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Regulation of signal transduction at M2 muscarinic receptor
Physiological Research, 2004 Muscarinic acetylcholine receptors mediate transmission of an extracellular signal represented by released acetylcholine to neuronal or effector cells. There are five subtypes of closely homologous muscarinic receptors which are coupled by means of heterotrimeric G-proteins to a variety of signaling pathways resulting in a multitude of target cell ...
A, Krejcí +4 more
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Journal of Pharmacological Sciences, 2013 Cholinergic nerve–mediated excitatory junction potentials (EJPs) in the longitudinal muscle of mouse ileum were characterized by using M2 or M3 muscarinic receptor–knockout (KO) mice and 1-[β-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole ...
Hayato Matsuyama +5 more
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Muscarinic receptor regulation of chronic pain-induced atrial fibrillation
Frontiers in Cardiovascular Medicine, 2022 Atrial fibrillation (AF), one of the most common arrhythmias, is associated with chronic emotional disorder. Chronic pain represents a psychological instability condition related to cardiovascular diseases, but the mechanistic linkage connecting chronic ...
Chao Gong +10 more
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Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. [PDF]
PLoS ONE, 2015 The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity
Franziska Mohr +3 more
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