Results 1 to 10 of about 13,945 (210)
Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor [PDF]
Membranes, 2015 The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
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Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]
Genes, 2013 Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Kühne, Sina +9 more
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Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments [PDF]
Journal of Biological Chemistry, 2004 Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single
Peter, J.C. +13 more
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Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity [PDF]
Scientific Reports, 2017 Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
Kurachi, Yoshihisa +5 more
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Voltage affects the dissociation rate constant of the m2 muscarinic receptor. [PDF]
PLoS ONE, 2013 G-protein coupled receptors (GPCRs) comprise the largest protein family and mediate the vast majority of signal transduction processes in the body. Until recently GPCRs were not considered to be voltage dependent.
Yair Ben Chaim +3 more
doaj +5 more sources
Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995 The relative distribution and absolute quantities of muscarinic receptor subtypes m1, m2, m3, and m4 were determined in membranes of canine trachealis muscle, bronchi, and lung parenchyma by immuno-precipitation with receptor subtype-specific rabbit ...
C. W. Emala +6 more
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Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]
Journal of Biochemistry, 2000 The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Haga, T., Furukawa, H.
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Biomedicines, 2023 (1) Background: SARS-CoV-2 infection has been linked to diverse clinical manifestations in humans, including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have emerged as potential contributors to these ...
Gerd Wallukat +4 more
doaj +1 more source
Biomolecules, 2022 The cross-talk between axon and glial cells during development and in adulthood is mediated by several molecules. Among them are neurotransmitters and their receptors, which are involved in the control of myelinating and non-myelinating glial cell ...
Roberta Piovesana +5 more
doaj +1 more source
Activation and dynamic network of the M2 muscarinic receptor [PDF]
Proceedings of the National Academy of Sciences, 2013 G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear.
Yinglong, Miao +4 more
openaire +2 more sources