Results 121 to 130 of about 3,288 (169)

Localization of the m5 muscarinic cholinergic receptor in rat circle of Willis and pial arteries

Neuroscience, 2003
The expression and microanatomical localization of the muscarinic cholinergic m5 receptor subtype was investigated in rat circle of Willis and pial arteries by in situ hybridization, immunoblotting and immunohistochemistry. In situ hybridization histochemistry revealed a strong signal in the endothelium of circle of Willis and pial arteries and a ...
TAYEBATI, Seyed Khosrow, DI TULLIO MA, TOMASSONI, Daniele, AMENTA, Francesco   +3 more
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Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors.

Molecular Pharmacology, 1992
The five muscarinic receptors (m1-m5), although structurally closely related, can be distinguished pharmacologically by the use of subtype-selective ligands. Various tricyclic muscarinic antagonists, including the AF-DX derivative AQ-RA 741 and the alkaloid himbacine, for example, have been shown to display up to 200-fold higher affinities for m2 and ...
J, Wess, D, Gdula, M R, Brann
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Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice

Psychopharmacology, 2007
Schizophrenic patients show decreased measures of sensorimotor gating, such as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to predict antipsychotic activity. While current antipsychotic drugs act largely at dopamine receptors, the muscarinic acetylcholine receptors offer promising novel pharmacotherapy ...
Thomsen, M., Wortwein, G., Fink-Jensen, Anders, Woldbye, D.P.D., Wess, J., Caine, S.B.   +5 more
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Evaluation of 1,2,5-thiadiazoles as modulators of M1/M5 muscarinic receptor subtypes

Bioorganic & Medicinal Chemistry, 2014
Abstract Studies have demonstrated the presence of allosteric binding sites on each of the muscarinic acetylcholine receptor (mAChR) subtypes. Since most drugs targeting muscarinic receptors bind to the highly conserved orthosteric binding site, they fail to achieve appreciable subtype selectivity. Targeting non-conserved allosteric sites may provide
Aditya Maheshwari, P.S.S. Rao, William S. Messer   +2 more
openaire   +1 more source

Immunological Detection of Muscarinic Receptor Subtype Proteins (m1–m5) in Rabbit Peripheral Tissues

Molecular Pharmacology, 1991
Employing subtype-specific antisera, we have measured the relative levels of five muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Immunoprecipitation assays demonstrated the presence of four distinct receptor proteins (m1-m4), which showed notable differences in their tissue distribution.
F, Dörje, A I, Levey, M R, Brann
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Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology

Life Sciences, 2003
Until recently, little was known about the possible physiological functions of the M(5) muscarinic acetylcholine receptor subtype, the last member of the muscarinic receptor family (M(1)-M(5)) to be cloned. To learn more about the potential physiological roles of this receptor subtype, we generated and analyzed M(5) receptor-deficient mice (M5 -/- mice)
Masahisa, Yamada, Anthony S, Basile, Irina, Fedorova, Weilie, Zhang, Alokesh, Duttaroy, Yinghong, Cui, Kathryn G, Lamping, Frank M, Faraci, Chu Xia, Deng, Jürgen, Wess   +9 more
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Activation mechanism of the M5 muscarinic acetylcholine receptor

Biophysical Journal, 2023
Lee Roy, A. De Velez, Jokent T. Gaza, Ricky B. Nellas   +3 more
openaire   +1 more source

Sensitization of Adenylyl Cyclase by P2 Purinergic and M5 Muscarinic Receptor Agonists in L Cells

Molecular Pharmacology, 1991
Many hormones have been shown to activate phospholipase C, which results in the hydrolysis of membrane polyphosphoinositides, such as phosphatidylinositol 4,5-bisphosphate (PIP2). Two second messengers are known to be produced by PIP2 hydrolysis, 1,2-diacylglycerol, an endogenous activator of a family of enzymes called protein kinase C (PKCs), and ...
J A, Johnson, J, Friedman, R D, Halligan, M, Birnbaumer, R B, Clark   +4 more
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Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry

Neuroscience Letters, 1990
The regional distribution of mRNA coding for the m5 muscarinic acetylcholine receptor subtype was investigated in tissue sections of rat brain by in situ hybridization histochemistry. The highest hybridization signal was observed in the hippocampus, but restricted to the ventral subiculum, pyramidal cells of the CA1 and, with lower intensity, of the ...
M T, Vilaró, J M, Palacios, G, Mengod
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Immunohistochemical study of m1–m5 muscarinic receptors and nNOS in human inferior turbinate mucosa

Acta Oto-Laryngologica, 2007
This study suggested that nitric oxide (NO) takes part in the parasympathetic nerve control functions mainly through m3 receptors and subsequently through m1 receptors.The regulation of glandular secretions and vasomotor tone in human nasal mucosa implicates muscarinic receptors. There are five recognized classes (m1-m5) of muscarinic receptor subtypes.
Muneo, Nakaya, Kenji, Kondo, Kimitaka, Kaga   +2 more
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