Molecular mechanisms for fetal cardiac arrhythmia in intrahepatic cholestasis of pregnancy
, 2010 Intrahepatic cholestasis in pregnancy (ICP) is characterized by raised serum bile acids which can cause fetal complications, including preterm labour and intrauterine death. The fetal death in ICP is not well understood. In this thesis, the mechanisms of
Sheikh Abdul Kadir, Siti Hamimah +1 more
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Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]
, 2018 The epithelial inner layer of the lower urinary tract, i.e., the urothelium, and other parts of the mucosa are not just a passive barrier but play an active role in the sensing of stretching, neurotransmitters, paracrine mediators, hormones, and growth ...
Chess-Williams, Russ +2 more
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BMC Genetics, 2007 Background The mesolimbic structures of the brain are important in the anticipation and perception of reward. Moreover, many drugs of addiction elicit their response in these structures.
Olsson Craig A +5 more
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Morphologic evaluation and Ca2+ mobilization by glicose and acetylcholine in human pancreatic cells [PDF]
, 2007 AIMS: The proposal of this study was to analyze morphology of the organelles and cytoskeleton in human pancreatic cells cultured and the mobilization of the cytosolic calcium ([Ca2+]c) in response to glucose and ACh by fluorimetry method.
Cardoso, Daniela Espinha +5 more
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Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]
, 2013 Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear.
Christopher Chapple +7 more
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Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]
, 2016 BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P +8 more
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AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway [PDF]
, 2012 The sorting of signaling receptors within the endocytic system is important for appropriate cellular responses. After activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosomes and degraded.
Dores, Michael R +5 more
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LifeWe tried to synthesize the possibilities of predicting the response to clozapine treatment, which can significantly improve the efficacy of the active substance and reduce adverse reactions, and how the active substance acts at the D1 dopaminergic ...
Mihai-Gabriel Năstase +3 more
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Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment [PDF]
, 2013 Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β1-adrenergic (β1AR) receptor monoclonal antibodies (mAbs).
Ali Jazayeri +18 more
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Adrenergic receptors. Models for regulation of signal transduction processes. [PDF]
, 1990 Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene.
Caron, MG +3 more
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