Results 91 to 100 of about 6,339 (219)
Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion
British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.Background and Purpose
Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer +9 morewiley +1 more sourceGPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman +3 morewiley +1 more sourceLight‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT
Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera +5 morewiley +1 more sourceTowards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier +6 morewiley +1 more sourceA Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction [PDF]
, 2016 The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid Aal-Aaboda, Agabio, Agrawal, Al' Absi, Albuquerque, Alhaddad, Alhaddad, Allen, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Anderson, Anton, Antuono, Assaad, Azmitia, Babor, Badia-Elder, Baimel, Bannai, Bannai, Barker, Barnes, Barron, Beart, Becker, Beckwith, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Bell, Benham, Bertholomey, Besheer, Besheer, Besheer, Bhaskar, Bhaskar, Bice, Bierut, Bito-Onon, Blednov, Blomqvist, Blume, Breslin, Brodie, Brodie, Brodie, Brunelle, Buisman-Pijlman, Burke, Bymaster, Cadoret, Calabresi, Campbell, Cao, Cao, Carlezon, Carr, Cederlof, Chandler, Chandler, Chappell, Charbogne, Chatterjee, Chatterjee, Chen, Chen, Cherpitel, Chester, Chiavegatto, Childress, Ciccocioppo, Ciccocioppo, Cicero, Clausen, Clerget, Clifford, Cloninger, Coleman, Conrod, Conrod, Contini, Coonfield, Cooper, Corrigall, Cosgrove, Cotton, Cowen, Cowen, Cozzoli, Crabbe, Crabbe, Crabbe, Crews, Cui, Cui, Czachowski, Danbolt, Das, Davis, Davis, Dawson, Deehan, Dhaher, Di Chiara, Dick, Dick, Dick, Ding, Ding, Domart, Draski, Drews, Drummond, Dumont, Dundon, Dyr, Economidou, Edenberg, Ehlers, Ehlers, Ehlers, Ehlers, Ehrenreich, Eiler, Eiler, Elman, Eng, Engel, Engleman, Engleman, Engleman, Engleman, Engleman, Engleman, Enna, Enoch, Enoch, Epstein, Ericson, Ericson, Ericson, Everitt, Eysenck, Fadda, Faria, Farris, Fetissov, Files, Filip, Finn, Finn, Fitzgerald, Flavin, Flory, Floyd, Foroud, Forray, Foster, Frances, Franklin, Franklin, Franklin, Fritschy, Froehlich, Froehlich, Froehlich, Gaiarsa, Gass, Gatto, Gedik, Gegelashvili, Geiger, George, Gerra, Gessa, Getachew, Gianoulakis, Gilpin, Gilpin, Gilpin, Gilpin, Gilpin, Gilpin, Gobrogge, Golan, Golbidi, Gold, Goldberg, Goldman, Gonzalez-Burgos, Goodman, Goodwani, Gorini, Gorini, Gotti, Grace, Gray, Greeley, Griffin, Grzywacz, Guan, Guillot, Guillot, Gulley, Gupta, Halliday, Hamilton, Hanchar, Haughey, Hauser, Hauser, Hauser, Heath, Heather, Hegerl, Heilig, Heilig, Heilig, Heilig, Heinz, Heinz, Heit, Hendrickson, Hendrickson, Henley, Herman, Herman, Hersch, Herve, Hesselbrock, Hesselbrock, Hinckers, Hrubec, Hulse, Hunt, Hwang, Hwang, Hwang, Imperato, Irimia, Ishii, Iyer, Jablon, Jerlhag, Jerlhag, Jerlhag, Johnson, Johnson, Johnson, Johnston, Johnston, Jonas, June, June, June, June, June, June, June, June, June, June, June, June, Jupp, Kaji, Kampov-Polevoy, Kane, Kapasova, Kaplan, Kaplan, Kaprio, Katner, Keating, Keith, Kelley, Kiefer, Kim, Kimpel, Kirby, Klimek, Koob, Koob, Koob, Koob, Koob, Koob, Koob, Koob, Koob, Korpi, Krishnan, Krishnan-Sarin, Krishnan-Sarin, Kryger, Kumar, Kuntsche, Kupila, Kurtz, Lancaster, Lankford, Le, Leggio, Lesch, Lester, Levy, Lex, Li, Li, Liang, Liang, Liang, Litten, Liu, Logrip, Lovinger, Lovinger, Lukas, Lukkes, Lumeng, Lumeng, Lumeng, Luo, Lynch, Lyness, Lê, Lê, Lê, Maccioni, Maccioni, Mackenzie, Madsen, Manzardo, Mardones, Mardones, Marini, Martin, Mason, Mason, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McCairn, McCarson, McClintick, McGehee, McGonigle, McHugh, McKinney, McLarnon, Meinhardt, Melendez, Melendez, Melis, Menkes, Milner, Mitani, Miyata, Mokdad, Moonat, Morean, Moreira, Moret, Morganstern, Morozova, Morris, Morzorati, Morzorati, Morzorati, Morzorati, Moss, Murphy, Murphy, Murphy, Murphy, Murphy, Murphy, Murphy, Nam, Nestler, Nevo, Newman, NIAAA, NIAAA National Advisory Council, Niciu, Nie, Nie, Nisell, Noble, Nogueira, Nordberg, Noronha, Nowak, Nowak, Nunez, Nutt, Obara, Okahisa, Olney, Oswald, Othman, Overstreet, Overstreet, O’Brien, Palmer, Pandey, Pandey, Pandey, Pandey, Panula, Parent, Parker, Parks, Partanen, Pautassi, Pessia, Peterson, Peterson, Pierce, Piercy, Pivac, Plemenitas, Ponomarev, Prelipceanu, Presley, Preuss, Preuss, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rajan, Rao, Rao, Rao, Rao, Rao, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Reed, Rehm, Rehm, Renthal, Research Society on Alcoholism, Research Society on Alcoholism, Reser, Reul, Reyes, Rezvani, Rezvani, Rezvani, Richardson, Richter, Riihioja, Robbins, Roberto, Roberts, Robinson, Robinson, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Rothstein, Russell, Saba, Sable, Saccone, Sahr, Sajdyk, Sajja, Sajja, Sajja, Sajja, Samson, Samson, Sari, Sari, Sari, Sari, Sari, Sartor, Sato, Sauvage, Schlaepfer, Schmidt, Schroeder, Schroeder, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Seal, Self, Shield, Shin, Silveri, Silveri, Simpson, Smialowska, Smith, Smith, Smith, Smith, Soderpalm, Soderpalm, Sofuoglu, Sommer, Sorbel, Spanagel, Spanagel, Spear, Spear, Spence, Spence, Stanley, Steensland, Stewart, Stewart, Stewart, Stewart, Stormark, Strobel, Strother, Strother, Strother, Szumlinski, Tabakoff, Tabakoff, Tanchuck, Terunuma, Thanos, Thiele, Thielen, Thielen, Thoma, Thorsell, Tizabi, Tizabi, Toalston, Toalston, Traynelis, Trim, Truitt, Van Bockstaele, Van Pett, Van Rizen, Varlinskaya, Varlinskaya, Vengeliene, Vengeliene, Verplaetse, Verplaetse, Vetreno, Viken, Vilaró, Volkow, Volkow, Walker, Waller, Waller, Waller, Wand, Wang, Wang, Wang, Wang, Wang, Warburton, Ward, Ward, Wechsler, Weiner, Weiss, Weitlauf, Wess, Wess, Wetherill, White, Whiteside, Williams, Williams, Wimalawansa, Windle, Wise, Witkin, Witt, Witt, Witt, Wolak, Wrase, Xuei, Yamada, Yan, Yang, Yong, Yoshimoto, Zeitzer, Zhang, Zhou, Zhou, Zhou, Zhou, Zhou, Zlojutro, Zucker, Zucker, Zuo, Zuo +647 morecore +1 more source
