Results 91 to 100 of about 40,413 (202)

Following the Action of Atypical Antipsychotic Clozapine and Possible Prediction of Treatment Response in Schizophrenia

Life
We tried to synthesize the possibilities of predicting the response to clozapine treatment, which can significantly improve the efficacy of the active substance and reduce adverse reactions, and how the active substance acts at the D1 dopaminergic ...
Mihai-Gabriel Năstase, Antonia Ioana Vasile, Arina Cipriana Pietreanu, Simona Trifu   +3 more
doaj   +1 more source

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj   +1 more source

Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity

ChemistryOpen
The present study was designed to measure the potential antiemetic properties of nerolidol (NDL) via in vivo and in silico studies. To induce emesis copper sulfate pentahydrate (CuSO4.5H2O) was administered at a dose of 50 mg/kg (orally) to 2‐day‐old ...
Sharmita Ghosh Situ, Md. Shimul Bhuia, Raihan Chowdhury, Md. Sakib Al Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Md. Arman Ali, Muhammad Torequl Islam   +7 more
doaj   +1 more source

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Scientific Reports
The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and in silico studies. To assess the effect, doses of 50 mg/kg b.w. copper sulfate (CuSO4⋅5H2O) were given orally to 2-day-old chicks. The test compound
Rubel Hasan, Abdulrahman Alshammari, Norah A. Albekairi, Md. Shimul Bhuia, Meher Afroz, Raihan Chowdhury, Muhammad Ali Khan, Siddique Akber Ansari, Irfan Aamer Ansari, Mohammad S. Mubarak, Muhammad Torequl Islam   +10 more
doaj   +1 more source

The mechanism of action and clinical efficacy of xanomeline-trospium in schizophrenia: A comprehensive review. [PDF]

Ther Adv Psychopharmacol
Ji F, Ma L, Shen X, Liang X, Cui W, Zhou Y, Wang XE, Liu H.   +7 more
europepmc   +1 more source

Role of Muscarinic Receptor Signaling Processes in Specific Aspects of Morphine-Induced Respiratory Depression in Rats. [PDF]

Pharmaceuticals (Basel)
Getsy PM, May WJ, Baby SM, Coffee GA, Qiu Y, Cheng F, Bates JN, Lewis SJ.   +7 more
europepmc   +1 more source

Emerging non-D₂ receptor-based therapies for schizophrenia: a focus on muscarinic and glutamatergic pathways. [PDF]

Front Psychiatry
Wang Y, Wang J, Zhang X, Liu X.
europepmc   +1 more source

L-Cysteine Ethyl Ester May Overcome Morphine-Induced Respiratory Depression by Activating Muscarinic Receptors. [PDF]

Pharmaceuticals (Basel)
Getsy PM, May WJ, Baby SM, Coffee GA, Forster HV, Hodges MR, Qiu Y, Cheng F, Bates JN, Lewis SJ.   +9 more
europepmc   +1 more source

Xanomeline-Trospium Validates Muscarinic Agonism as an Effective Non-Dopaminergic Treatment for Schizophrenia. [PDF]

Int J Mol Sci
Mansour GK, Hajjar AW, Hajjar AH, Alissa A, Sukkarieh HH.   +4 more
europepmc   +1 more source

Muscarinic Receptor PET in Neurodegeneration: Promise, Pitfalls, and Translational Priorities. [PDF]

Med Sci (Basel)
Filippi L, Danieli R.
europepmc   +1 more source