Results 71 to 80 of about 6,339 (219)
Pharmacology Research & Perspectives, 2022 Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M4 and M5 mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD).
Leigh C. Walker +5 more
doaj +1 more source
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, Volume 604, Issue 4, Page 1531-1546, 15 February 2026.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
On the role of G protein-coupled receptors oligomerization [PDF]
, 2013 The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community.
Ahern, Siobhán +3 more
core +2 more sources
Food Frontiers, Volume 7, Issue 1, January 2026.ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu +9 more
wiley +1 more source
Alcohol addiction: a molecular biology perspective. [PDF]
, 2015 Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero +2 more
core +1 more source
Spirocyclic Diamine Scaffolds for Medicinal Chemistry
Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel +3 more
wiley +1 more source
Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]
, 2013 Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura +20 more
core +2 more sources
Journal of Ophthalmology, Volume 2026, Issue 1, 2026.Myopia has emerged as a major global public health concern. Atropine, recognized as one of the foremost interventions for myopia control, has been validated for its efficacy and safety through a multitude of clinical studies. This article examines the most recent advancements in understanding atropine’s mechanisms of action, optimizing dosage ...
Qinling Jiang +4 more
wiley +1 more source
G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]
, 2009 Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]
, 2007 G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
core +1 more source