Results 61 to 70 of about 40,413 (202)

The Interactions Between Acetylcholine and T‐Cells and Their Role in the Immune System: A Scoping Review

Immunology, EarlyView.
Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Physiological functions of the cholinergic system in immune cells

Journal of Pharmacological Sciences, 2017
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase (ChAT), muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and ...
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

Journal of Pharmacological Sciences, 2007
We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model.
Qi Zhao, Yukihisa Murakami, Michihisa Tohda, Ryosuke Obi, Yutaka Shimada, Kinzo Matsumoto   +5 more
doaj   +1 more source

Potentiation of Muscarinic M3 Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302

Journal of Pharmacology and Experimental Therapeutics, 2021
Muscarinic M3 (M3) receptors mediate a wide range of acetylcholine (ACh)-induced functions, including visceral smooth-muscle contraction and glandular secretion.
Risa Okimoto, Katsutoshi Ino, Kenichiro Ishizu, H. Takamatsu, K. Sakamoto, H. Yuyama, Hideyoshi Fuji, Akiyoshi Someya, Akiyoshi Ohtake, T. Ishigami, N. Masuda, M. Takeda, S. Kajioka, N. Yoshimura   +13 more
semanticscholar   +1 more source

Regulation of cell spreading during differentiation in the muscarinic M5 receptor tumor-suppressor model [PDF]

International Journal of Cancer, 1997
Activation of the muscarinic receptor in Chinese hamster ovary (CHO) cells results in a reversal of the malignant phenotype for which spreading into a bipolar, fibroblastic morphology is a marker. The process of morphologic change requires multiple events, including alterations in adhesions to substrates and cytoskeletal re-arrangement. In this report,
J R, Spoonster, L, Masiero, S A, Savage, J, Probst, E C, Kohn   +4 more
openaire   +2 more sources

Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Frontiers in Pharmacology, 2020
Dequalinium is used as an antimicrobial compound for oral health and other microbial infections. Derivatives of dequalinium, the bis-quinolinium cyclophanes UCL 1684 and UCL 1848, are high affinity SK potassium channel antagonists.
Vladislav Bugay, Derek J. Wallace, Bin Wang, Irving Salinas, Adriana Paola Chapparo, Hudson Ryan Smith, Peter Herbert Dube, Edward G. Brooks, Edward G. Brooks, Kelly Ann Berg, Robert Brenner   +10 more
doaj   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Expression and Function of the Cholinergic System in Immune Cells

Frontiers in Immunology, 2017
T and B cells express most cholinergic system components—e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively).
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Pyrrolo-pyridazine Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators.

ACS Medicinal Chemistry Letters, 2021
Important Compound Classes. Title. Pyrrolo-pyridazine Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators Patent Application Number. WO 2020/079606A1 Publication Date. April 23, 2020 Priority Application.
B. Blass
semanticscholar   +1 more source