Results 51 to 60 of about 40,413 (202)

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Neurotherapeutics, 2022
Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by developmental regression, loss of communicative ability, stereotyped hand wringing, cognitive impairment, and central apneas, among many other symptoms.
Mackenzie Smith, Bright Arthur, Jakub J Cikowski, Calista Holt, S. Gonzalez, Nicole M. Fisher, S. Vermudez, C. Lindsley, C. Niswender, Rocco G. Gogliotti   +9 more
semanticscholar   +1 more source

Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects

Plants, 2023
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the current study is to assess the potential antiemetic properties of QUA using an in vivo and ...
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib, Rubel Hasan, Henrique Douglas Melo Coutinho, Isaac Moura Araújo, Irwin Rose Alencar de Menezes, Muhammad Torequl Islam   +7 more
doaj   +1 more source

The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma

Journal of Cellular Biochemistry, 2022
Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized the expression
M. Taggi, Andjela Kovacevic, C. Capponi, M. Falcinelli, Veronica Cacciamani, E. Vicini, R. Canipari, A. Tata   +7 more
semanticscholar   +1 more source

Identification of a regulatory sequence within the third intracellular loop that governs β-arrestin binding to the muscarinic M5 receptor.

Cellular Signalling
The M5 muscarinic acetylcholine receptor (M5R) is selectively expressed in dopaminergic neurons and although accounts for
S. Steinmüller, K. Thompson, J. Alenfelder, J. Drube, C. Hoffmann, E. Kostenis, D. Thompson, J. Hislop   +7 more
semanticscholar   +1 more source

Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats.

Neuropharmacology, 2020
Acetylcholine is implicated in mood disorders including depression and anxiety. Increased cholinergic tone in humans and rodents produces pro-depressive and anxiogenic-like effects.
E. Nunes, Laura E. Rupprecht, Daniel J. Foster, C. Lindsley, P. Conn, N. Addy   +5 more
semanticscholar   +1 more source

Computational Evaluation of Substituted 2-Aminopyrimidine Schiff Bases as Potential Antidepressant Targeting the Muscarinic Acetylcholine M5 Receptor

Journal of Neonatal Surgery
The effectiveness of existing treatments for depression, a complicated mental health condition that affects people all over the world, is limited. The ability of the muscarinic acetylcholine receptor subtype M5 (M5 mAChR) to modulate dopaminergic and ...
Smita Sunil Sawalwade, Bhavna Utkarsh Jain, Sonali Sanjay Nikam, Snehal Prakash Patil   +3 more
semanticscholar   +1 more source

Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor

Journal of Medicinal Chemistry
While the muscarinic acetylcholine receptor mAChR subtype 5 (M5) has been studied over decades, recent findings suggest that more in-depth research is required to elucidate a thorough understanding of its physiological function related to neurological ...
Jinming Li, Douglas L. Orsi, Julie L. Engers, Madeline F. Long, Rory A. Capstick, Mallory A. Maurer, C. Presley, P. Vinson, Alice L. Rodriguez, Allie Han, Hyekyung P. Cho, Si-Chen Chang, Megan Jackson, M. Bubser, A. L. Blobaum, Olivier Boutaud, Michael A. Nader, C. Niswender, P. J. Conn, Carrie K. Jones, C. Lindsley, Chang-Ho Han   +21 more
semanticscholar   +1 more source

Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease

International Journal of Molecular Sciences, 2021
The parasympathetic nervous system is critically involved in the regulation of tear secretion by activating muscarinic acetylcholine receptors. Hence, various animal models targeting parasympathetic signaling have been developed to induce dry eye disease
A. Musayeva, Su-Bao Jiang, Yue Ruan, J. K. Zadeh, P. Chronopoulos, N. Pfeiffer, W. Müller, M. Ackermann, N. Xia, Hui-Ge Li, A. Gericke   +10 more
semanticscholar   +1 more source

Activation of Muscarinic Acetylcholine Receptor Subtype 4 is Essential for Cholinergic Stimulation of Gastric Acid Secretion - Relation To D Cell/Somatostatin -

Frontiers in Pharmacology, 2016
Background/Aim: Muscarinic acetylcholine receptors exist in five subtypes (M1~M5), and they are widely expressed in various tissues to mediate diverse autonomic functions, including gastric secretion.
Koji Takeuchi, Koji Takeuchi, Takuya Endoh, Shusaku Hayashi, Takeshi Aihara   +4 more
doaj   +1 more source

Whole‐Genome Sequencing and Resequencing of Hucho bleekeri Provides Insights into Genetic Mechanisms of Environmental Adaptation

Integrative Zoology, EarlyView.
A high‐quality chromosome‐level reference genome was constructed for Hucho bleekeri. Population structure and environmental adaptation of Hucho species were revealed by whole‐genome resequencing. ABSTRACT Salmonidae represents an important family in the study of genome evolution following genome duplication.
Yeyu Chen, Huanchao Yang, Zhao Liu, Xiaoyun Wu, Qinyao Wei, Yanling Chen, Jue Lin, Yi Yu, Quanyu Tu, Hua Li   +9 more
wiley   +1 more source