Results 51 to 60 of about 6,339 (219)

Crystal structure of the M ₅ muscarinic acetylcholine receptor [PDF]

Proceedings of the National Academy of Sciences, 2019
Abstract The human M 5 muscarinic acetylcholine receptor (mAChR) has recently emerged as an exciting therapeutic target for treating a range of disorders, including drug addiction.
Ziva Vuckovic, Patrick R. Gentry, Alice E. Berizzi, Kunio Hirata, Swapna Varghese, Geoff Thompson, Emma T. van der Westhuizen, Wessel A.C. Burger, Raphaёl Rahmani, Celine Valant, Christopher J. Langmead, Craig W. Lindsley, Jonathan Baell, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos, David M. Thal   +16 more
openaire   +3 more sources

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source

Expression and function of G-protein-coupled receptorsin the male reproductive tract [PDF]

, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
ABOUD R, ALONSO-LLAMAZARES A, ANAND-IVELL RJ, ANDERSON MB, BAN Y, BATHGATE RA, BATHGATE RA, BERNARD V, BERNARD V, BHATHAL PS, BIRDSALL NJ, BISHOP MJ, BLANCO M, BOGIC L, BORGES MOR, BRADDON SA, BRODDE OE, BURAZIN TC, BURT RP, BURT RP, CAMPOS M, Catarina S. Porto, CAULFIELD MP, CHALOTHORN D, CHAN HC, CHANG DJ, CHATURAPANICH G, CHEAH SH, CHEN S, CHEN S, COGÉ F ET AL, DA SILVA MC, DALY CJ, DANIELS DV, DAVENPORT CW, DEBRUYNE FM, DENG XF, DIVIANI D, DOCHERTY JR, DOCHERTY JR, DOGGRELL SA, DU JY, EGLEN RM, EGLEN RM, EHRÉN I, EISENHOFER G, ERRASTI AE, ESBENSHADE TA, ESSIG M, FENG S, FEVOLD HL, FILONZI M, FORD APDW, FORD APDW, FORRAY C, FUKASAWA R, GAO B, GAO B, GOBEIL F JR, GONZÁLEZ-ESPINOSA C, GRAHAM RM, GRIMM U, GUNNERSEN JM, GUNNERSEN JM, HAAG C, HAGUE C, HAGUE C, HALLS ML, HALLS ML, HALLS ML, HAMAMURA M, HANFT G, HANSELL DJ, HAUSER F, HAWRYLYSHYN KA, HEIN P, HIB J, HIB J, HIEBLE JP, HIEBLE JP, HIRASAWA A, HIRASAWA A, HIRASAWA A, HISAW FL, HOMMA Y, HORIE K, HROMETZ SL, HSU SY, HSU SY, HU K, HULEIHEL M, HULME EC, HWA J, HWA J, HWA J, II M, IRAM S, IVELL R, IVELL R, JACKSON VM, JEYABALAN A, JEYABALAN A, JIANG X, JOCKENHOVEL F, JUDSON DG, JURKIEWICZ NH, KAMAT AA, KARKANIAS GB, KERN A, KIM JK, KINGHORN EM, KOHSAKA T, KONDO S, KRAJNC-FRANKEN MA, KUBO T, KUDO M, LACEY JP, LANGER S, LANZAFAME AA, LAU WA, LAZ TM, LEEB-LUNDBERG LM, LEFKOWITZ RJ, LEFKOWITZ RJ, LEFKOWITZ RJ, LENHART JA, LEPOR H, LEUNG AYH, LIU C, LOCKWOOD DH, LONGHURST PA, LOPEZ-GIMENEZ JF, LUCAS TFG, LUCAS TFG, LUTHIN GR, MACDONALD A, MACKENZIE JF, MACKINNON AC, MALLARD NJ, MANNI L, MANNI L, Maria Christina W. Avellar, Maria Fatima M. Lázari, MARKUS RP, MARÓSTICA E, MARÓSTICA E, MCCUNE DF, MCCUNE SK, MENDES FR, MICHELOTTI GA, MICHELOTTI GA, MIRANDA HF, MIRANDA HF, MIRANDA HF, MOOKERJEE I, MORIYAMA N, MORROW AL, MURAMATSU I, MURRAY KT, NADELHAFT I, NAKAOKA H, NASU K, NASU K, NEWINGER J, NISHIS, NOTHACKER HP, OBARA K, PAPATSORIS AG, PATRÃO MT, PEDRETTI A, PEREZ DM, PETITTI N, PIASCIK MT, PIASCIK MT, PIASCIK MT, PONTARI MA, PORTER JE, PRENZEL N, PRICE DT, PRICE DT, PRICE RR, PUPO AS, PUPO AS, QUEIRÓZ DB, QUEIRÓZ DBC, QUESADA A, RAMARAO CS, RAMSAY D, RATNASOORIYA WD, RATNASOORIYA WD, RAYFORD W, RICKER DD, ROEHRBORN CG, ROKOSH DG, ROKOSH DG, RUDNER XL, RUFFOLO RR JR, RUGGIERI MR, SALAMANCA AE, SALLÉS J, SAMUEL CS, SAMUEL CS, SAMUEL CS, SANBE A, SANBORN BM, SAROSI P, SATO T, SAUSSY DL JR, SAWUTZ DG, SCARPARO AC, SCHWINN DA, SCHWINN DA, SCOFIELD MA, SCOTT DJ, SCOTT DJ, SHANNON HE, SHAPIRO E, SHEN H, SHERWOOD OD, SHIMA S, SHINOURA H, SILVA MA, SIU ER, SKINNER MK, SOKOL RZ, STEINETZ BG, SUDO S, SUGAWARA T, SUZUKI F, TAYEBATI SK, TENG CM, TENSEN CP, TESTA R, THEBAULT S, THEROUX TL, TOEWS ML, UBERTI MA, UBERTI MA, VAN DIJK MM, VAN KOPPEN CJ, VARMA DR, VENTURA S, VICENTIC A, VIVAS NM, VÁZQUEZ-PRADO J, WALDEN PD, WALKER WH, WANG JM, WANG X ET AL, WAUGH DJ, WESS J, WIER WG, XIAO L, XU Z, YAN HH, YANG M, YANG-FENG TL, YANG-FENG TL, YASUOKA A, YAZAWA H, YAZAWA H, YKI-JARVINEN H, YOSHINAGA T, ZHAO L, ZHONG H, ZHONG H, ZIMMERMANN S, ZUSCIK MJ   +267 more
core   +3 more sources

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]

, 2010
To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core   +2 more sources

Dopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons [PDF]

, 2011
Mesostriatal dopaminergic neurons and striatal cholinergic interneurons participate in signaling the motivational signifcance of environmental stimuli and regulate striatal plasticity. Dopamine (DA) and acetylcholine (ACh) have potent interactions within
Sarah Threlfell, Stephanie Jane Cragg
core   +3 more sources

Activation of Muscarinic Acetylcholine Receptor Subtype 4 is Essential for Cholinergic Stimulation of Gastric Acid Secretion - Relation To D Cell/Somatostatin -

Frontiers in Pharmacology, 2016
Background/Aim: Muscarinic acetylcholine receptors exist in five subtypes (M1~M5), and they are widely expressed in various tissues to mediate diverse autonomic functions, including gastric secretion.
Koji Takeuchi, Koji Takeuchi, Takuya Endoh, Shusaku Hayashi, Takeshi Aihara   +4 more
doaj   +1 more source

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo, Antje Banning, Boman, Bonner, Caulfield, Caumont, Cheng, Claing, Coso, Crespo, Dascher, Delaney, Elorza, Ferguson, Fisher, Franco, Frucht, Grando, Grando, Hawes, Hawes, He, Hein, Hulme, Jin, Jones, Jones, Lee, Lee, Leiros, Lenhard, McCole, Michal, Miyakawa, Nguyen, Pals-Rylaarsdam, Pals-Rylaarsdam, Pitcher, Prenzel, Reiner, Ritva Tikkanen, Roseberry, Rosenblum, Shah, Simone Bocksberger, Sina Kühne, Taylor, Tohgo, Tsuga, van Biesen, van Koppen, Vogler, Vogler, Wang, Wickman, Williams, Wu, Wymke Ockenga, Zhang   +58 more
core   +3 more sources

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Claudia Guerriero, Chiara De Nuccio, Maria Petrone, Teresa Rinaldi, Angela Cirigliano, Sergio Visentin, Antonietta Bernardo, Luciano Conti, Carlo Matera, Marco De Amici, Clelia Dallanoce, Ada Maria Tata   +11 more
wiley   +1 more source

Muscarinic Modulation of High Frequency Oscillations in Pedunculopontine Neurons [PDF]

, 2013
We previously reported that persistent application of the non-specific cholinergic agonist carbachol (CAR) increased the frequency of calcium channel-mediated oscillatory activity in pedunculopontine nucleus (PPN) neurons, which we identified as ...
Belen Goitia, Edgar Garcia-Rill, Francisco J. Urbano, James Hyde, Nebojsa Kezunovic, Veronica Bisagno   +5 more
core   +2 more sources