Results 161 to 170 of about 40,413 (202)

Immunohistochemical study of m1–m5 muscarinic receptors and nNOS in human inferior turbinate mucosa

Acta Oto-Laryngologica, 2007
This study suggested that nitric oxide (NO) takes part in the parasympathetic nerve control functions mainly through m3 receptors and subsequently through m1 receptors.The regulation of glandular secretions and vasomotor tone in human nasal mucosa implicates muscarinic receptors. There are five recognized classes (m1-m5) of muscarinic receptor subtypes.
Muneo, Nakaya, Kenji, Kondo, Kimitaka, Kaga   +2 more
openaire   +2 more sources

Constitutive Activation of the m5 Muscarinic Receptor by a Series of Mutations at the Extracellular End of Transmembrane 6

Biochemistry, 1997
The m5 muscarinic acetylcholine receptor was constitutively activated by a wide range of amino acid substitutions at a residue (serine 465) that is positioned at the junction of the sixth transmembrane domain and the extracellular loop. Of 13 substitutions tested, 11 produced significant increases in constitutive activity.
T A, Spalding, E S, Burstein, J W, Wells, M R, Brann   +3 more
openaire   +2 more sources

A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor

2010
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
openaire   +1 more source

Design and Synthesis of Dualsteric Muscarinic M5 Receptor Ligands Reveal G Protein Bias

ACS Chemical Neuroscience
The M5 muscarinic acetylcholine receptor (M5R) is selectively expressed in dopaminergic neurons where it plays a key role in modulating dopaminergic activity, making it a promising target for neuropsychiatric disorders. Selectively targeting the M5R remains challenging due to high orthosteric site conservation across all five muscarinic acetylcholine ...
Sophie A. M. Steinmüller, Alix C. Flake, Marcel Bermudez, Peter Ashdown, James N. Hislop, Michael Decker   +5 more
openaire   +2 more sources

Pharmacology of a constitutively activated m5 muscarinic receptor

Life Sciences, 1995
T.A. Spalding, E.S. Burstein, H.B. Jørgensen, D. Hill-Eubanks, M.R. Brann   +4 more
openaire   +1 more source

Muscarinic Acetylcholine Receptors Subtypes M1–M5 in the Somatic Muscles of Earthworm Lumbricus terrestris

Cell and Tissue Biology, 2022
L. Nurullin, E. Volkov
semanticscholar   +1 more source

Pharmacological Effects of Turmeric on Learning, Memory and Expression of Muscarinic Receptor Genes (M1, M3 and M5) in Stress-induced Mouse Model.

Current Drug Targets, 2017
Aliya Khalid, Rabia Shakeel, Saira Justin, Ghazala Iqbal, S. Shah, Saadia Zahid, T. Ahmed   +6 more
semanticscholar   +1 more source

Antisense oligonucleotide for the m5 muscarinic receptor in the ventral tegmentum reduces M5 receptor density, but not scopolamine-induced locomotion

Life Sciences, 1999
R.P.M. Priebe, A.S. Kumar, D.D. Flynn, J. Fulton, J.S. Yeomans   +4 more
openaire   +1 more source

Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy.

ACS Chemical Neuroscience, 2021
Matthew C L Wakeham, B. J. Davie, David K. Chalmers, A. Christopoulos, B. Capuano, C. Valant, P. Scammells   +6 more
semanticscholar   +1 more source

Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

, 2019
Z. Vuckovic, A. Christopoulos, D. Thal
semanticscholar   +1 more source