Results 21 to 30 of about 3,288 (169)

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ. [PDF]

PLoS ONE, 2015
Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal ...
Marta Słoniecka, Sandrine Le Roux, Peter Boman, Berit Byström, Qingjun Zhou, Patrik Danielson   +5 more
doaj   +1 more source

Voltage Dependence of Muscarinic M1-,M3- and M5 Receptors [PDF]

Biophysical Journal, 2014
Muscarinic receptors (MR) are G protein-coupled receptors (GPCRs). Localized to the plasma membrane, they sense changes of the membrane potential and exhibit voltage-dependent signaling. Because voltage activates Gq-coupled receptors (e.g. M1R) but deactivates Gi-coupled receptors (e.g.
Rinne, Andreas, Mobarec, Juan-Carlos, Kolb, Peter, Bünemann, Moritz   +3 more
openaire   +1 more source

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein

Toxins, 2011
Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja, Johnny Näsman, Sergio Rondinelli   +2 more
doaj   +1 more source

Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. [PDF]

PLoS ONE, 2011
BACKGROUND: The maintenance of the intestinal epithelium is of great importance for the survival of the organism. A possible nervous control of epithelial cell renewal was studied in rats and mice.
Ove Lundgren, Mats Jodal, Madeleine Jansson, Anders T Ryberg, Lennart Svensson   +4 more
doaj   +1 more source

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source

Synthesis and anticancer activity of 1,2,4-Benzothiadiazine-1,1-dioxides

Results in Chemistry, 2023
After heart disease, cancer is one of the most intimidating diseases. Currently in the world, cancer has been established to be one of the utmost daunting illnesses in the world today, amongst several human ailments.
Sumit Chhabra, Kamal Shah
doaj   +1 more source

Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators [PDF]

Molecular Pharmacology, 2016
Recently, the first subtype-selective allosteric modulators of the M5 muscarinic acetylcholine receptor (mAChR) have been described, but their molecular mechanisms of action remain unknown. Using radioligand-binding and functional assays of inositol phosphate (IP) accumulation and Ca(2+) mobilization in a recombinant cell line stably expressing the ...
Alice E, Berizzi, Patrick R, Gentry, Patricia, Rueda, Sandra, Den Hoedt, Patrick M, Sexton, Christopher J, Langmead, Arthur, Christopoulos   +6 more
openaire   +2 more sources

Update on the Development of SUVN‐I6107: A True Positive Allosteric Modulator of the Muscarinic M1 Acetylcholine Receptor for the Treatment of Dementia [PDF]

Alzheimers Dement
Abstract Background SUVN‐I6107 is a novel and selective muscarinic M1 Positive Allosteric Modulator (PAM) being developed for the treatment of dementia due to neurodegenerative disorders. In the current research, the pharmacological properties of SUVN‐I6107 in various animal models of cognitive deficits were investigated.
Benade V, Shinde A, Badange R, Rasheed M, Subramanian R, Petlu S, Abraham R, Goyal V, Palacharla V, Goura V, Pandey S, Medapati R, Kallepalli R, Nirogi R.   +13 more
europepmc   +2 more sources

Cognitive Impairment, Sleep Disturbance, and Depression in Women with Silicone Breast Implants: Association with Autoantibodies against Autonomic Nervous System Receptors

Biomolecules, 2022
Background: Silicone breast implants (SBIs) has been shown to be associated with an increased risk of autoimmune diseases. In the current study, we aimed to explore the potential association between circulating autoantibodies against the autonomic ...
Milena Tocut, Gilad Halpert, Avishai M. Tsur, Kassem Sharif, Harald Heidecke, Yair Levy, Abdulla Watad, Howard Amital, Yehuda Shoenfeld   +8 more
doaj   +1 more source