Results 11 to 20 of about 40,413 (202)

Muscarinic Acetylcholine Receptor M5

Definitions, 2020
Muscarinic acetylcholine receptor M5 (532 aa, ~60 kDa) is encoded by the human CHRM5 gene. This protein plays a role in both acetylcholine binding and G protein-coupled receptor signaling.

semanticscholar   +2 more sources

Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum

The Journal of Pharmacology and Experimental Therapeutics, 2023
The type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located to modulate DA signaling and ...
Vivien Zell, G. Teuns, A. S. Needham, Sruti Mukherjee, Nathaniel Roscoe, Michelle Le, L. Fourgeaud, G. Woodruff, Anindya Bhattacharya, Mathieu Marella, Pascal Bonaventure, Wayne C. Drevets, B. Balana   +12 more
semanticscholar   +3 more sources

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell–cell junctions [PDF]

Reproduction, 2021
Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility; however, the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet.
Xiao Han, Cong Zhang, Xiangping Ma, Xiaowei Yan, Bohui Xiong, W. Shen, Shen Yin, Hong-Fu Zhang, Qingyuan Sun, Yong Zhao   +9 more
semanticscholar   +3 more sources

Muscarinic M5 receptors modulate ethanol seeking in rats [PDF]

Neuropsychopharmacology, 2018
Despite the cost to both individual and society, alcohol use disorders (AUDs) remain a major health risk within society, and both relapse and heavy drinking are still poorly controlled with current medications. Here we demonstrate for the first time that
Alice E. Berizzi, C. Perry, David M. Shackleford, C. Lindsley, Carrie K. Jones, Nicola A. Chen, P. Sexton, A. Christopoulos, C. Langmead, A. Lawrence   +9 more
semanticscholar   +4 more sources

Crystal structure of the M5 muscarinic acetylcholine receptor [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance The 5 subtypes of the muscarinic acetylcholine receptors (mAChRs) are expressed throughout the central and peripheral nervous system where they play a vital role in physiology and pathologies. Recently, the M5 mAChR subtype has emerged as an
Ziva Vuckovic, P. R. Gentry, Alice E. Berizzi, K. Hirata, Swapna Varghese, G. Thompson, E. T. van der Westhuizen, Wessel A. C. Burger, Raphaël Rahmani, C. Valant, C. Langmead, C. Lindsley, J. Baell, A. Tobin, P. Sexton, A. Christopoulos, D. Thal   +16 more
semanticscholar   +4 more sources

M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

Pharmacology Research & Perspectives, 2022
Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M4 and M5 mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD).
Leigh C. Walker, Erin J. Campbell, Kate L. Huckstep, Nicola A. Chen, Christopher J. Langmead, Andrew J. Lawrence   +5 more
doaj   +2 more sources

Exploring the Evolving Role of Scopolamine in Pharmacotherapy: From Cognitive Impairment to Neuroplasticity?―A Narrative Review [PDF]

Molecules
Scopolamine, also known as hyoscine, is a naturally occurring tropane alkaloid derived from plants of the Solanaceae family. Clinically, the compound has long been used for the prevention of motion sickness and postoperative nausea and vomiting, as well ...
Jakub Kukla, Piotr Olejnik, Kaja Kasarełło   +2 more
doaj   +2 more sources

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR [PDF]

Nature Communications
The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding site poses significant challenges for drug development.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal   +13 more
doaj   +2 more sources

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science. [PDF]

Clin Transl Sci
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Avila S, Chen IL.
europepmc   +2 more sources

Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis

Biomolecules, 2023
The Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M1, M4, and M5
J. Wierońska, P. Cieślik, G. Burnat, L. Kalinowski   +3 more
semanticscholar   +1 more source