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Receptors for Nerve Growth Factor
1993Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
David S. Battleman +2 more
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THE RECEPTORS FOR NERVE GROWTH FACTOR AND OTHER NEUROTROPHINS
Annual Review of Biochemistry, 1993OVERVIEW .. . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 823 HISTORICAL ASPECTS . . . . . . . .. . . . . . . . . .. . . . . . . . . . .. . . . . . . . 825 MOLECULAR PROPERTIES . . . . . . . . . . . . . . . . ... . . . . .. . . .... . . . 827 Low-Molecular-Weight Receptor (LNGFR; p75) . l.:' . • . . . . . . . . . .
Ralph A. Bradshaw +2 more
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European Journal of Oral Sciences, 2012
Nerve growth factor (NGF) is a pluripotent mediator that is present in a range of human tissues. Nerve growth factor was originally considered important only in neuronal homeostasis and pathophysiology, but later it was also implicated in the pathophysiology of inflammation, epithelial differentiation, and wound healing. In this study, the distribution
Elsebeth P. Næsse +4 more
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Nerve growth factor (NGF) is a pluripotent mediator that is present in a range of human tissues. Nerve growth factor was originally considered important only in neuronal homeostasis and pathophysiology, but later it was also implicated in the pathophysiology of inflammation, epithelial differentiation, and wound healing. In this study, the distribution
Elsebeth P. Næsse +4 more
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Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2002Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1).
Giovanni Piedimonte +4 more
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Effect of retinoic acid on nerve growth factor receptors [PDF]
Cell and Tissue Research, 1987 Retinoic acid (RA), a naturally occurring metabolite of vitamin A, increased the number of receptors for nerve growth factor (NGF) in cultured human neuroblastoma cells (LA-N-1), as indicated by an immunofluorescence assay of cell surface receptors and by specific binding of 125I-NGF to solubilized receptors. Analysis of 125I-NGF binding showed that RA
Robert W. Stach +3 more
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Nerve growth factor: two receptors, multiple functions
BioEssays, 1998Nerve growth factor (NGF) was characterized over 4 decades ago, and like the other neurotrophins subsequently discovered, it is best known for its trophic role, including the prevention of programmed cell death in specific populations of neurones in the peripheral nervous system. This property can be accounted for by the activation of a tyrosine kinase
Frade, J. M., Barde, Y. A.
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Regulation of the Synthesis of Nerve Growth Factor and Nerve Growth Factor Receptor
1988The importance of Nerve Growth Factor (NGF) for the development and the maintenance of differentiated properties of peripheral sympathetic and neural crest- derived sensory neurons as well as for basal forebrain cholinergic neurons is well established (cf Levi-Montalcini & Angeletti, 1968; Greene & Shooter, 1980; Thoenen & Barde, 1980; Thoenen et al ...
Hans Thoenen +7 more
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Nerve Growth Factor Receptors and Signaling in Breast Cancer
Current Cancer Drug Targets, 2004Nerve growth factor (NGF) has long been known for its effects on neuronal cell survival and differentiation. This prototypical neurotrophic factor stimulates neurons through two distinct classes of membrane receptors: the TrkA tyrosine kinase receptor, and the tumor necrosis factor receptor family member p75NTR, also known as the common neurotrophin ...
Dollé, Laurent +5 more
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The nerve growth factor/tumor necrosis factor receptor family
Journal of Leukocyte Biology, 1996Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin +3 more
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Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors
1991The pioneering investigations of Levi-Montalcini and coworkers established that nerve growth factor (NGF) is an important physiological regulator of neurons of the peripheral nervous system. No doubt in part because of the dramatic and specific effects on the sympathetic and sensory nervous system resulting from immunochemically depriving rodents of ...
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