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The Structure and Expression of the Nerve Growth Factor Receptors
1990Neurotrophic factors, of the type characterized by nerve growth factor (NGF, Levi-Montalcini, 1987) are synthesized in limiting amounts in, and secreted from, the target cells of the innervated neurons and then carried by retrograde flow from the nerve terminal to the neuronal cell body (Thoenen and Barde, 1980).
Susan O. Meakin +5 more
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Journal of Neurochemistry, 1987
Abstract: We have used biologically active derivatives of β‐nerve growth factor (NGF), modified by biotinylation via carboxyl groups, to target the specific binding of liposomes to cultured rat and human tumor cells bearing NGF receptors. Liposomes, to be used for targeting, were prepared by conjugating streptavidin to phospholipid amino groups on ...
Edward Hawrot +2 more
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Abstract: We have used biologically active derivatives of β‐nerve growth factor (NGF), modified by biotinylation via carboxyl groups, to target the specific binding of liposomes to cultured rat and human tumor cells bearing NGF receptors. Liposomes, to be used for targeting, were prepared by conjugating streptavidin to phospholipid amino groups on ...
Edward Hawrot +2 more
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Journal of Neuroscience Research, 1992
AbstractGlucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells.
Jose R. Perez-Polo +4 more
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AbstractGlucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells.
Jose R. Perez-Polo +4 more
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Nerve growth factor receptors in the central nervous system
Experimental Neurology, 1988Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has ...
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European Journal of Neuroscience, 1990
AbstractSensory neurons of the adult rat dorsal root ganglion (DRG) can be maintained in culture in the absence of nerve growth factor (NGF). We have thus used dissociated cultures of these neurons to study effects of NGF on the regulation of expression of mRNA encoding the nerve growth factor receptor (NGF‐R).
Dan Lindholm +6 more
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AbstractSensory neurons of the adult rat dorsal root ganglion (DRG) can be maintained in culture in the absence of nerve growth factor (NGF). We have thus used dissociated cultures of these neurons to study effects of NGF on the regulation of expression of mRNA encoding the nerve growth factor receptor (NGF‐R).
Dan Lindholm +6 more
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Molecular Brain Research, 1992
The synthesis of nerve growth factor (NGF) and nerve growth factor receptor (NGFR) were studied in a C6 glioma cell line by Northern blot hybridization. In response to a glutamate agonist N-methyl-D-aspartic acid (NMDA), NGF mRNA increased by up to 2-fold after 4-12 h of culture.
Fumio Hishinuma +5 more
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The synthesis of nerve growth factor (NGF) and nerve growth factor receptor (NGFR) were studied in a C6 glioma cell line by Northern blot hybridization. In response to a glutamate agonist N-methyl-D-aspartic acid (NMDA), NGF mRNA increased by up to 2-fold after 4-12 h of culture.
Fumio Hishinuma +5 more
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The Nerve Growth Factor Receptor: Biochemical and Structural Analysis
1989Publisher Summary This chapter reviews the biochemical characterization of the human nerve growth factor (NGF) receptor and the expression and molecular cloning of the receptor after gene transfer into heterologous cells. It also discusses the structural features of the receptor in relation to its many functional responses.
Barbara L. Hempstead, Moses V. Chao
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Acute Regulation of the Epidermal Growth Factor Receptor in Response to Nerve Growth Factor
Journal of Neurochemistry, 1991Abstract: PC12 cells possess specific receptors for both nerve growth factor and epidermal growth factor, and by an unknown mechanism, nerve growth factor is able to attenuate the propagation of a mitogenic response to epidermal growth factor.
Graham Carpenter, Alice B. Brown
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Molecular modelling studies of a nerve growth factor receptor
Canadian Journal of Chemistry, 1998Using computer simulations, a geometry for the receptor binding site for nerve growth factor (NGF) has been proposed. Variable basis Monte Carlo simulated annealing calculations have been used to ascertain the structures of the complexes of four fully active NGF analogues with the second leucine-rich motif (LRM-2) of trkA, a putative binding site for ...
Donald F. Weaver +3 more
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