Results 61 to 70 of about 284,983 (313)

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

eLife, 2016
Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator.
Xiang Zhou, Qian Hao, Peng Liao, Shiwen Luo, Minhong Zhang, Guohui Hu, Hongbing Liu, Yiwei Zhang, Bo Cao, Melody Baddoo, Erik K Flemington, Shelya X Zeng, Hua Lu   +12 more
doaj   +1 more source

Effects of 1,25-Vitamin D3 and 24,25-Vitamin D3 on Corneal Nerve Regeneration in Diabetic Mice

Biomolecules, 2023
Corneal nerve homeostasis is essential for the functional integrity of the ocular surface. Vitamin D deficiency (VDD) and vitamin D receptor knockout (VDR KO) have been found to reduce corneal nerve density in diabetic mice.
Xiaowen Lu, Zhong Chen, Jerry Lu, Mitchell A. Watsky   +3 more
doaj   +1 more source

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

an immunohistochemical study [PDF]

, 2016
Background The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB,
Dewanto, Agung, Dudas, Jozsef, Glueckert, Rudolf, Mechsner, Sylvia, Schrott-Fischer, Anneliese, Seeber, Beata, Wildt, Ludwig   +6 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats

Stem Cell Research & Therapy, 2021
Background Nerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth factor and cytokines.
Diego Noé Rodríguez-Sánchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andréa Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha, Rogério Martins Amorim   +13 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Effect of estrogen on growth and development of nerve cell in cerebellum of rat

浙江大学学报. 农业与生命科学版, 2008
In order to study the effect of estrogen on the development and neurocrine of nerve cell culture vitro of cerebellum, select the nerve cell of cerebellum of one day rat, then observe the growth and development of nerve cell after treatment with 17β ...
CHEN Zheng-li, LUO Qi-hui, FAN Guang-li
doaj   +1 more source